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A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives
Joint Authors
Abdoulaye, Idriss Ali
Guo, Yi Jing
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The research of alternative treatment for ischemic stroke and degenerative diseases has always been a priority in neurology.
3-N-Butylphthalide (NBP), a family of compounds initially isolated from the seeds of Apium graveolens Linn., has shown significant neuroprotective effects.
Previous extensive studies have demonstrated that NBP promotes a better poststroke outcome and exerts a multitargeted action on several mechanisms, from oxidative stress to mitochondrial dysfunction to apoptosis to inflammation.
Additionally, recent findings on several neurological disorders have shown that NBP’s beneficial effects extend beyond the management of stroke.
However, despite the increasing number of studies toward a better understanding and the rapid advances made in therapeutic options, to date, dl-3-N-butylphthalide, a synthetic variation of l-3-N-butylphthalide, remains the only clinically approved anti-ischemic agent in China, stressing the difficulties for a viable and effective transition from experimental to clinical practice.
Events indicate that NBP, due to its multitargeted effect and the adaptability of its basic structure, can be an important game changer and a precursor to a whole new therapeutic approach to several neurological conditions.
The present review discusses recent advances pertaining to the neuroprotective mechanisms of NBP-derived compounds and the possibility of their clinical implementation in the management of various neurological conditions.
American Psychological Association (APA)
Abdoulaye, Idriss Ali& Guo, Yi Jing. 2016. A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097974
Modern Language Association (MLA)
Abdoulaye, Idriss Ali& Guo, Yi Jing. A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097974
American Medical Association (AMA)
Abdoulaye, Idriss Ali& Guo, Yi Jing. A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097974