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7,8-DHF Treatment Induces Cyr61 Expression to Suppress Hypoxia Induced ER Stress in HK-2 Cells
Joint Authors
Ma, Rui
Zhang, Jisheng
Liu, Xiaoyu
Yue, Shaoheng
Zhao, Qing
Xu, Yan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Acute kidney injury (AKI) is a common syndrome which is strongly linked to high morbidity and mortality.
Hypoxia is the leading cause of AKI and the proximal renal tubular cells are the most damaged part in the kidney during this period.
It has been observed that 7,8-dihydroxyflavone (7,8-DHF) plays a protective role by acting on antiapoptosis and antioxidative stress.
In this study we explored functions of 7,8-DHF in protecting human proximal tubular cell line HK-2 from hypoxia insults.
We observed that treatment of 7,8-DHF could improve the viability of ischemic cell.
Mechanistically, we found that 7,8-DHF could elevate the expression of cysteine-rich protein 61 (Cyr61), a protective immediate early gene in AKI.
In addition, treatment of 7,8-DHF decreased CCAAT/enhancer-binding protein homologous protein (CHOP) expression, which is a marker protein during endoplasmic reticulum (ER) stress activation.
Intriguingly, overexpression of Cyr61 significantly reduced CHOP expression.
Taken together, our results provide novel insights into the possible protective role of 7,8-DHF by activating Cyr61 signaling and suppressing ER stress in hypoxic HK-2 cells which have potential clinical implications for the treatment of AKI.
American Psychological Association (APA)
Ma, Rui& Zhang, Jisheng& Liu, Xiaoyu& Yue, Shaoheng& Zhao, Qing& Xu, Yan. 2016. 7,8-DHF Treatment Induces Cyr61 Expression to Suppress Hypoxia Induced ER Stress in HK-2 Cells. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097977
Modern Language Association (MLA)
Ma, Rui…[et al.]. 7,8-DHF Treatment Induces Cyr61 Expression to Suppress Hypoxia Induced ER Stress in HK-2 Cells. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1097977
American Medical Association (AMA)
Ma, Rui& Zhang, Jisheng& Liu, Xiaoyu& Yue, Shaoheng& Zhao, Qing& Xu, Yan. 7,8-DHF Treatment Induces Cyr61 Expression to Suppress Hypoxia Induced ER Stress in HK-2 Cells. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097977