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An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus
Joint Authors
Shetty, Rohit
Nuijts, Rudy M. M. A.
Nagaraja, Harsha
Jayadev, Chaitra
Pahuja, Natasha Kishore
Agrawal, Aarti
Ghosh, Arkasubhra
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
To study the corneal nerve morphology and its importance in unilateral keratoconus.
Materials and Methods.
In this prospective cross-sectional study, 33 eyes of 33 patients with keratoconus in one eye (Group 3) were compared with the other normal eye of the same patients (Group 2) and 30 eyes of healthy patients (Group 1).
All patients underwent detailed ophthalmic examination followed by topography with Pentacam HR and in vivo confocal microscopy (IVCM).
Five images obtained with IVCM were analyzed using an automated CCmetrics software version 1.0 for changes in subbasal plexus of nerves.
Results.
Intergroup comparison showed statistically significant reduction in corneal nerve fiber density (CNFD) and length (CNFL) in Group 3 as compared to Group 1 (p<0.001 and p=0.001, resp.) and Group 2 (p=0.01 and p=0.02, resp.).
Though corneal nerve fiber length, diameter, area, width, corneal nerve branch density, and corneal total branch density were found to be higher in decentered cones, only the corneal nerve branch density (CNBD) was found to be statistically significant (p<0.01) as compared to centered cones.
Conclusion.
Quantitative changes in the corneal nerve morphology can be used as an imaging marker for the early diagnosis of keratoconus before the onset of refractive or topography changes.
American Psychological Association (APA)
Pahuja, Natasha Kishore& Shetty, Rohit& Nuijts, Rudy M. M. A.& Agrawal, Aarti& Ghosh, Arkasubhra& Jayadev, Chaitra…[et al.]. 2016. An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097996
Modern Language Association (MLA)
Pahuja, Natasha Kishore…[et al.]. An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1097996
American Medical Association (AMA)
Pahuja, Natasha Kishore& Shetty, Rohit& Nuijts, Rudy M. M. A.& Agrawal, Aarti& Ghosh, Arkasubhra& Jayadev, Chaitra…[et al.]. An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097996