Diagnostic Value of Magnetic Resonance Spectroscopy in Radiation Encephalopathy Induced by Radiotherapy for Patients with Nasopharyngeal Carcinoma: A Meta-Analysis
Joint Authors
Chen, Wang-Sheng
Li, Jian-Jun
Hong, Lan
Xing, Zeng-Bao
Wang, Fen
Li, Chang-Qing
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In this study, articles in English and Chinese were selected from available electronic databases prior to September 2014.
The metabolic concentrations and patterns of N-acetylaspartic acid (NAA), Choline (Cho), Creatine (Cr), NAA/Cr, NAA/Cho, and Cho/Cr ratios in radiotherapy-induced radiation encephalopathy by proton magnetic resonance spectroscopy were extracted.
A meta-analysis was performed to quantitatively synthesize findings of these studies.
Weighted mean difference (WMD) and 95% confidence intervals (95%CIs) were calculated using random or fixed effective models.
Heterogeneity between studies was assessed using the Cochrane Q test and I2 statistics.
The results indicated that a total of 4 researches involving 214 patients met inclusion criteria.
Depending on methodologies of selected studies, control groups were referred to as healthy subjects.
The combined analysis revealed that there was no significant difference in value of Cr between radiotherapy group and healthy control group (WMD = −1.483, 95% CI: −67.185–64.219, p=0.965).
However, there were significant difference in values of NAA (WMD = −18.227, 95%CI: −36.317–−0.137, p=0.048), Cho (WMD = 38.003, 95%CI: 5.155–70.851, p=0.023), NAA/Cr (WMD = −1.175, 95%CI: −1.563–−0.787, p=0.000), NAA/Cho (WMD = −1.108, 95%CI: −2.003–0.213, p=0.015), and Cho/Cr (WMD = −0.773, 95%CI: 0.239–1.307, p=0.005).
In conclusion, MRS can be regarded as an effective and feasible imaging test for radiotherapy-induced radiation encephalopathy in NPC patients.
American Psychological Association (APA)
Chen, Wang-Sheng& Li, Jian-Jun& Hong, Lan& Xing, Zeng-Bao& Wang, Fen& Li, Chang-Qing. 2016. Diagnostic Value of Magnetic Resonance Spectroscopy in Radiation Encephalopathy Induced by Radiotherapy for Patients with Nasopharyngeal Carcinoma: A Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098008
Modern Language Association (MLA)
Chen, Wang-Sheng…[et al.]. Diagnostic Value of Magnetic Resonance Spectroscopy in Radiation Encephalopathy Induced by Radiotherapy for Patients with Nasopharyngeal Carcinoma: A Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098008
American Medical Association (AMA)
Chen, Wang-Sheng& Li, Jian-Jun& Hong, Lan& Xing, Zeng-Bao& Wang, Fen& Li, Chang-Qing. Diagnostic Value of Magnetic Resonance Spectroscopy in Radiation Encephalopathy Induced by Radiotherapy for Patients with Nasopharyngeal Carcinoma: A Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098008
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098008