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The Occurrence of Genetic Alterations during the Progression of Breast Carcinoma
Joint Authors
Huang, Tao
Li, Xiao-Chen
Liu, Chenglin
Zhong, Yang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The interrelationship among genetic variations between the developing process of carcinoma and the order of occurrence has not been completely understood.
Interpreting the mechanisms of copy number variation (CNV) is absolutely necessary for understanding the etiology of genetic disorders.
Oncogenetic tree is a special phylogenetic tree inferential pictorial representation of oncogenesis.
In our present study, we constructed oncogenetic tree to imitate the occurrence of genetic and cytogenetic alterations in human breast cancer.
The oncogenetic tree model was built on CNV of ErbB2, AKT2, KRAS, PIK3CA, PTEN, and CCND1 genes in 963 cases of tumors with sequencing and CNA data of human breast cancer from TCGA.
Results from the oncogenetic tree model indicate that ErbB2 copy number variation is the frequent early event of human breast cancer.
The oncogenetic tree model based on the phylogenetic tree is a type of mathematical model that may eventually provide a better way to understand the process of oncogenesis.
American Psychological Association (APA)
Li, Xiao-Chen& Liu, Chenglin& Huang, Tao& Zhong, Yang. 2016. The Occurrence of Genetic Alterations during the Progression of Breast Carcinoma. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1098068
Modern Language Association (MLA)
Li, Xiao-Chen…[et al.]. The Occurrence of Genetic Alterations during the Progression of Breast Carcinoma. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1098068
American Medical Association (AMA)
Li, Xiao-Chen& Liu, Chenglin& Huang, Tao& Zhong, Yang. The Occurrence of Genetic Alterations during the Progression of Breast Carcinoma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1098068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098068