Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences
Joint Authors
McElvaney, Noel G.
Lavelle, Gillian
White, Michelle M.
Browne, Niall
Reeves, Emer P.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-01
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
The resultant characteristic ion transport defect results in decreased mucociliary clearance, bacterial colonisation, and chronic neutrophil-dominated inflammation.
Much knowledge surrounding the pathophysiology of the disease has been gained through the generation of animal models, despite inherent limitations in each.
The failure of certain mouse models to recapitulate the phenotypic manifestations of human disease has initiated the generation of larger animals in which to study CF, including the pig and the ferret.
This review will summarise the basic phenotypes of three animal models and describe the contributions of such animal studies to our current understanding of CF.
American Psychological Association (APA)
Lavelle, Gillian& White, Michelle M.& Browne, Niall& McElvaney, Noel G.& Reeves, Emer P.. 2016. Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences. BioMed Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1098073
Modern Language Association (MLA)
Lavelle, Gillian…[et al.]. Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences. BioMed Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1098073
American Medical Association (AMA)
Lavelle, Gillian& White, Michelle M.& Browne, Niall& McElvaney, Noel G.& Reeves, Emer P.. Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1098073
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098073