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miR-145a-5p Promotes Myoblast Differentiation
Joint Authors
Du, Jingjing
Li, Qiang
Shen, Linyuan
Lei, Huaigang
Luo, Jia
Liu, Yihui
Zhang, Peiwen
Pu, Qiang
Zhang, Yi
Shuai, Surong
Li, Xuewei
Zhang, Shunhua
Zhu, Li
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
MicroRNAs are a class of 18–22-nucleotide noncoding RNAs that posttranscriptionally regulate gene expression and have been shown to play an important role during myoblast differentiation.
In this study, we found that the expression of miR-145a-5p was gradually increased during C2C12 myoblast differentiation, and miR-145a-5p inhibitors or mimics significantly suppressed or promoted the relative expression of specific myogenesis related marker genes.
Moreover, overexpression or inhibition of miR-145a-5p enhanced or repressed the expression of some special genes involved in the endogenous Wnt signaling pathway during C2C12 myoblast differentiation, including Wnt5a, LRP5, Axin2, and β-catenin.
These results indicated that miR-145a-5p might be considered as a new myogenic differentiation-associated microRNA that can promote C2C12 myoblast differentiation by enhancing genes related to myoblasts differentiation.
American Psychological Association (APA)
Du, Jingjing& Li, Qiang& Shen, Linyuan& Lei, Huaigang& Luo, Jia& Liu, Yihui…[et al.]. 2016. miR-145a-5p Promotes Myoblast Differentiation. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098076
Modern Language Association (MLA)
Du, Jingjing…[et al.]. miR-145a-5p Promotes Myoblast Differentiation. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1098076
American Medical Association (AMA)
Du, Jingjing& Li, Qiang& Shen, Linyuan& Lei, Huaigang& Luo, Jia& Liu, Yihui…[et al.]. miR-145a-5p Promotes Myoblast Differentiation. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098076