Maraviroc-Mediated Lung Protection following Trauma-Hemorrhagic Shock
Joint Authors
Yu, Huang-Ping
Liu, Fu-Chao
Zheng, Chih-Wen
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
The peroxisome proliferator-activated receptor gamma (PPARγ) pathway exerts anti-inflammatory effects in response to injury.
Maraviroc has been shown to have potent anti-inflammatory effects.
The aim of this study was to investigate whether PPARγ plays an important role in maraviroc-mediated lung protection following trauma-hemorrhage.
Methods.
Male Sprague-Dawley rats underwent trauma-hemorrhage (mean blood pressure maintained at approximately 35–40 mmHg for 90 minutes), followed by fluid resuscitation.
During resuscitation, a single dose of maraviroc (3 mg/kg, intravenously) with and without a PPARγ inhibitor GW9662 (1 mg/kg, intravenously), GW9662, or vehicle was administered.
Lung water content, tissue histology, and other various parameters were measured ( n = 8 rats/group) 24 hours after resuscitation.
One-way ANOVA and Tukey’s testing were used for statistical analysis.
Results.
Trauma-hemorrhage significantly increased lung water content, myeloperoxidase activity, intercellular adhesion molecule-1, interleukin-6, and interleukin-1β levels.
These parameters significantly improved in the maraviroc-treated rats subjected to trauma-hemorrhage.
Maraviroc treatment also decreased lung tissue damage as compared to the vehicle-treated trauma-hemorrhaged rats.
Coadministration of GW9662 with maraviroc abolished the maraviroc-induced beneficial effects on these parameters and lung injury.
Conclusion.
These results suggest that PPARγ might play a key role in maraviroc-mediated lung protection following trauma-hemorrhage.
American Psychological Association (APA)
Liu, Fu-Chao& Zheng, Chih-Wen& Yu, Huang-Ping. 2016. Maraviroc-Mediated Lung Protection following Trauma-Hemorrhagic Shock. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098080
Modern Language Association (MLA)
Liu, Fu-Chao…[et al.]. Maraviroc-Mediated Lung Protection following Trauma-Hemorrhagic Shock. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098080
American Medical Association (AMA)
Liu, Fu-Chao& Zheng, Chih-Wen& Yu, Huang-Ping. Maraviroc-Mediated Lung Protection following Trauma-Hemorrhagic Shock. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098080