Prenatal Evaluation of MicroRNA Expressions in Pregnancies with Down Syndrome
Joint Authors
Gunduz, Cumhur
Ergenoglu, Ahmet Mete
Erturk, Biray
Aykut, Ayca
Guler, Ahmet
Buke, Baris
Ozkinay, Ferda
Ozeren, Mehmet
Kazandi, Mert
Sagol, Sermet
Karaca, Emin
Cogulu, Ozgur
Akercan, Fuat
Yeniel, Ahmet Ozgur
Durmaz, Burak
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Currently, the data available on the utility of miRNAs in noninvasive prenatal testing is insufficient in the literature.
We evaluated the expression levels of 14 miRNAs located on chromosome 21 in maternal plasma and their utility in noninvasive prenatal testing of Down Syndrome.
Method.
A total of 56 patients underwent invasive prenatal testing; 23 cases were carrying Down Syndrome affected fetuses, and 33 control cases carrying unaffected, normal karyotype fetuses were included for comparison.
Indications for invasive prenatal testing were advanced maternal age, increased risk of Down Syndrome in screening tests, and abnormal finding in the sonographic examination.
In both the study and control groups, all the pregnant women were at 17th and 18th week of gestation.
miRNA expression levels were measured using real-time RT-PCR.
Results.
Significantly increased maternal plasma levels of miR-3156 and miR-99a were found in the women carrying a fetus with Down Syndrome.
Conclusion.
Our results provide a basis for multicenter studies with larger sample groups and microRNA profiles, particularly with the microRNAs which were found to be variably expressed in our study.
Through this clinical research, the utility of microRNAs in noninvasive prenatal testing can be better explored in future studies.
American Psychological Association (APA)
Erturk, Biray& Karaca, Emin& Aykut, Ayca& Durmaz, Burak& Guler, Ahmet& Buke, Baris…[et al.]. 2016. Prenatal Evaluation of MicroRNA Expressions in Pregnancies with Down Syndrome. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1098083
Modern Language Association (MLA)
Erturk, Biray…[et al.]. Prenatal Evaluation of MicroRNA Expressions in Pregnancies with Down Syndrome. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1098083
American Medical Association (AMA)
Erturk, Biray& Karaca, Emin& Aykut, Ayca& Durmaz, Burak& Guler, Ahmet& Buke, Baris…[et al.]. Prenatal Evaluation of MicroRNA Expressions in Pregnancies with Down Syndrome. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1098083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098083