Prenatal Evaluation of MicroRNA Expressions in Pregnancies with Down Syndrome

Joint Authors

Gunduz, Cumhur
Ergenoglu, Ahmet Mete
Erturk, Biray
Aykut, Ayca
Guler, Ahmet
Buke, Baris
Ozkinay, Ferda
Ozeren, Mehmet
Kazandi, Mert
Sagol, Sermet
Karaca, Emin
Cogulu, Ozgur
Akercan, Fuat
Yeniel, Ahmet Ozgur
Durmaz, Burak

Source

BioMed Research International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-03-24

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Medicine

Abstract EN

Background.

Currently, the data available on the utility of miRNAs in noninvasive prenatal testing is insufficient in the literature.

We evaluated the expression levels of 14 miRNAs located on chromosome 21 in maternal plasma and their utility in noninvasive prenatal testing of Down Syndrome.

Method.

A total of 56 patients underwent invasive prenatal testing; 23 cases were carrying Down Syndrome affected fetuses, and 33 control cases carrying unaffected, normal karyotype fetuses were included for comparison.

Indications for invasive prenatal testing were advanced maternal age, increased risk of Down Syndrome in screening tests, and abnormal finding in the sonographic examination.

In both the study and control groups, all the pregnant women were at 17th and 18th week of gestation.

miRNA expression levels were measured using real-time RT-PCR.

Results.

Significantly increased maternal plasma levels of miR-3156 and miR-99a were found in the women carrying a fetus with Down Syndrome.

Conclusion.

Our results provide a basis for multicenter studies with larger sample groups and microRNA profiles, particularly with the microRNAs which were found to be variably expressed in our study.

Through this clinical research, the utility of microRNAs in noninvasive prenatal testing can be better explored in future studies.

American Psychological Association (APA)

Erturk, Biray& Karaca, Emin& Aykut, Ayca& Durmaz, Burak& Guler, Ahmet& Buke, Baris…[et al.]. 2016. Prenatal Evaluation of MicroRNA Expressions in Pregnancies with Down Syndrome. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1098083

Modern Language Association (MLA)

Erturk, Biray…[et al.]. Prenatal Evaluation of MicroRNA Expressions in Pregnancies with Down Syndrome. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1098083

American Medical Association (AMA)

Erturk, Biray& Karaca, Emin& Aykut, Ayca& Durmaz, Burak& Guler, Ahmet& Buke, Baris…[et al.]. Prenatal Evaluation of MicroRNA Expressions in Pregnancies with Down Syndrome. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1098083

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1098083