Application of PKPD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction
Joint Authors
Ahmad, Ijaz
Huang, Lingli
Hao, Haihong
Sanders, Pascal
Yuan, Zonghui
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Among veterinary drugs, antibiotics are frequently used.
The true mean of antibiotic treatment is to administer dose of drug that will have enough high possibility of attaining the preferred curative effect, with adequately low chance of concentration associated toxicity.
Rising of antibacterial resistance and lack of novel antibiotic is a global crisis; therefore there is an urgent need to overcome this problem.
Inappropriate antibiotic selection, group treatment, and suboptimal dosing are mostly responsible for the mentioned problem.
One approach to minimizing the antibacterial resistance is to optimize the dosage regimen.
PK/PD model is important realm to be used for that purpose from several years.
PK/PD model describes the relationship between drug potency, microorganism exposed to drug, and the effect observed.
Proper use of the most modern PK/PD modeling approaches in veterinary medicine can optimize the dosage for patient, which in turn reduce toxicity and reduce the emergence of resistance.
The aim of this review is to look at the existing state and application of PK/PD in veterinary medicine based on in vitro, in vivo, healthy, and disease model.
American Psychological Association (APA)
Ahmad, Ijaz& Huang, Lingli& Hao, Haihong& Sanders, Pascal& Yuan, Zonghui. 2016. Application of PKPD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098122
Modern Language Association (MLA)
Ahmad, Ijaz…[et al.]. Application of PKPD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1098122
American Medical Association (AMA)
Ahmad, Ijaz& Huang, Lingli& Hao, Haihong& Sanders, Pascal& Yuan, Zonghui. Application of PKPD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098122