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Longitudinal Comparison of Enzyme- and Laser-Treated Intervertebral Disc by MRI, X-Ray, and Histological Analyses Reveals Discrepancies in the Progression of Disc Degeneration: A Rabbit Study
Joint Authors
Fusellier, Marion
Colombier, Pauline
Lesoeur, Julie
Youl, Samy
Madec, Stéphane
Gauthier, Olivier
Hamel, Olivier
Guicheux, Jérôme
Clouet, Johann
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Regenerative medicine is considered an attractive prospect for the treatment of intervertebral disc (IVD) degeneration.
To assess the efficacy of the regenerative approach, animal models of IVD degeneration are needed.
Among these animal models, chemonucleolysis based on the enzymatic degradation of the Nucleus Pulposus (NP) is often used, but this technique remains far from the natural physiopathological process of IVD degeneration.
Recently, we developed an innovative animal model of IVD degeneration based on the use of a laser beam.
In the present study, this laser model was compared with the chemonucleolysis model in a longitudinal study in rabbits.
The effects of the treatments were studied by MRI (T2-weighted signal intensity (T2wsi)), radiography (IVD height index), and histology (NP area and Boos’ scoring).
The results showed that both treatments induced a degeneration of the IVD with a decrease in IVD height and T2wsi as well as NP area and an increase in Boos’ scoring.
The enzyme treatment leads to a rapid and acute process of IVD degeneration.
Conversely, laser radiation induced more progressive and less pronounced degeneration.
It can be concluded that laser treatment provides an instrumental in vivo model of slowly evolving IVD degenerative disease that can be of preclinical relevance for assessing new prophylactic biological treatments of disc degeneration.
American Psychological Association (APA)
Fusellier, Marion& Colombier, Pauline& Lesoeur, Julie& Youl, Samy& Madec, Stéphane& Gauthier, Olivier…[et al.]. 2016. Longitudinal Comparison of Enzyme- and Laser-Treated Intervertebral Disc by MRI, X-Ray, and Histological Analyses Reveals Discrepancies in the Progression of Disc Degeneration: A Rabbit Study. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098147
Modern Language Association (MLA)
Fusellier, Marion…[et al.]. Longitudinal Comparison of Enzyme- and Laser-Treated Intervertebral Disc by MRI, X-Ray, and Histological Analyses Reveals Discrepancies in the Progression of Disc Degeneration: A Rabbit Study. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1098147
American Medical Association (AMA)
Fusellier, Marion& Colombier, Pauline& Lesoeur, Julie& Youl, Samy& Madec, Stéphane& Gauthier, Olivier…[et al.]. Longitudinal Comparison of Enzyme- and Laser-Treated Intervertebral Disc by MRI, X-Ray, and Histological Analyses Reveals Discrepancies in the Progression of Disc Degeneration: A Rabbit Study. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098147