Optimal Control Model of Tumor Treatment with Oncolytic Virus and MEK Inhibitor
Joint Authors
Su, Yongmei
Jia, Chen
Chen, Ying
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tumors are a serious threat to human health.
The oncolytic virus is a kind of tumor killer virus which can infect and lyse cancer cells and spread through the tumor, while leaving normal cells largely unharmed.
Mathematical models can help us to understand the tumor-virus dynamics and find better treatment strategies.
This paper gives a new mathematical model of tumor therapy with oncolytic virus and MEK inhibitor.
Stable analysis was given.
Because mitogen-activated protein kinase (MEK) can not only lead to greater oncolytic virus infection into cancer cells, but also limit the replication of the virus, in order to provide the best dosage of MEK inhibitors and balance the positive and negative effect of the inhibitors, we put forward an optimal control problem of the inhibitor.
The optimal strategies are given by theory and simulation.
American Psychological Association (APA)
Su, Yongmei& Jia, Chen& Chen, Ying. 2016. Optimal Control Model of Tumor Treatment with Oncolytic Virus and MEK Inhibitor. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098152
Modern Language Association (MLA)
Su, Yongmei…[et al.]. Optimal Control Model of Tumor Treatment with Oncolytic Virus and MEK Inhibitor. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098152
American Medical Association (AMA)
Su, Yongmei& Jia, Chen& Chen, Ying. Optimal Control Model of Tumor Treatment with Oncolytic Virus and MEK Inhibitor. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098152
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098152