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The Epithelial Sodium Channel and the Processes of Wound Healing
Joint Authors
Hernández, Julio A.
Chifflet, Silvia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The epithelial sodium channel (ENaC) mediates passive sodium transport across the apical membranes of sodium absorbing epithelia, like the distal nephron, the intestine, and the lung airways.
Additionally, the channel has been involved in the transduction of mechanical stimuli, such as hydrostatic pressure, membrane stretch, and shear stress from fluid flow.
Thus, in vascular endothelium, it participates in the control of the vascular tone via its activity both as a sodium channel and as a shear stress transducer.
Rather recently, ENaC has been shown to participate in the processes of wound healing, a role that may also involve its activities as sodium transporter and as mechanotransducer.
Its presence as the sole channel mediating sodium transport in many tissues and the diversity of its functions probably underlie the complexity of its regulation.
This brief review describes some aspects of ENaC regulation, comments on evidence about ENaC participation in wound healing, and suggests possible regulatory mechanisms involved in this participation.
American Psychological Association (APA)
Chifflet, Silvia& Hernández, Julio A.. 2016. The Epithelial Sodium Channel and the Processes of Wound Healing. BioMed Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1098160
Modern Language Association (MLA)
Chifflet, Silvia& Hernández, Julio A.. The Epithelial Sodium Channel and the Processes of Wound Healing. BioMed Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1098160
American Medical Association (AMA)
Chifflet, Silvia& Hernández, Julio A.. The Epithelial Sodium Channel and the Processes of Wound Healing. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1098160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098160