Reconstruction for Limited-Projection Fluorescence Molecular Tomography Based on a Double-Mesh Strategy

Abstract EN

Limited-projection fluorescence molecular tomography (FMT) has short data acquisition time that allows fast resolving of the three-dimensional visualization of fluorophore within small animal in vivo.

However, limited-projection FMT reconstruction suffers from severe ill-posedness because only limited projections are used for reconstruction.

To alleviate the ill-posedness, a feasible region extraction strategy based on a double mesh is presented for limited-projection FMT.

First, an initial result is rapidly recovered using a coarse discretization mesh.

Then, the reconstructed fluorophore area in the initial result is selected as a feasible region to guide the reconstruction using a fine discretization mesh.

Simulation experiments on a digital mouse and small animal experiment in vivo are performed to validate the proposed strategy.

It demonstrates that the presented strategy provides a good distribution of fluorophore with limited projections of fluorescence measurements.

Hence, it is suitable for reconstruction of limited-projection FMT.