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Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis
Joint Authors
Lin, Hailong
Zhou, Jian
Lin, Kaichun
Wang, Hongjiao
Liang, Zunhong
Ren, Xingshuai
Huang, Leting
Xia, Chan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study aimed to evaluate the clinical efficacy and safety of using the traditional Chinese herbal medicine Scutellaria baicalensis for the treatment of severe HFMD in 725 patients aged >1 year in a multicenter, retrospective analysis.
The patients were divided into the S.
baicalensis and ribavirin groups, and the temperatures, presence or absence of skin rashes and oral lesions, nervous system (NS) involvement, and viral loads of the patients, as well as the safety of the treatments, were evaluated.
The median duration of fever, median time to NS involvement, and the number of patients with oral ulcers and/or vesicles, as well as skin rashes, were decreased in the S.
baicalensis group compared with the ribavirin group.
In addition, the EV71 viral loads were decreased in the S.
baicalensis group, suggesting that S.
baicalensis exerted more potent antiviral effects compared with ribavirin.
The present study demonstrated that S.
baicalensis was suitable for the treatment of severe HFMD in patients aged >1 year, since it was shown to rapidly relieve fever, attenuate oral lesions and rashes, and improve NS involvement.
Furthermore, it was demonstrated to be relatively safe for topical application.
American Psychological Association (APA)
Lin, Hailong& Zhou, Jian& Lin, Kaichun& Wang, Hongjiao& Liang, Zunhong& Ren, Xingshuai…[et al.]. 2016. Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098169
Modern Language Association (MLA)
Lin, Hailong…[et al.]. Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098169
American Medical Association (AMA)
Lin, Hailong& Zhou, Jian& Lin, Kaichun& Wang, Hongjiao& Liang, Zunhong& Ren, Xingshuai…[et al.]. Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098169