E -Index for Differentiating Complex Dynamic Traits
Joint Authors
Wang, Jianxin
Qi, Jiandong
Sun, Jianfeng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
While it is a daunting challenge in current biology to understand how the underlying network of genes regulates complex dynamic traits, functional mapping, a tool for mapping quantitative trait loci (QTLs) and single nucleotide polymorphisms (SNPs), has been applied in a variety of cases to tackle this challenge.
Though useful and powerful, functional mapping performs well only when one or more model parameters are clearly responsible for the developmental trajectory, typically being a logistic curve.
Moreover, it does not work when the curves are more complex than that, especially when they are not monotonic.
To overcome this inadaptability, we therefore propose a mathematical-biological concept and measurement, E -index (earliness-index), which cumulatively measures the earliness degree to which a variable (or a dynamic trait) increases or decreases its value.
Theoretical proofs and simulation studies show that E -index is more general than functional mapping and can be applied to any complex dynamic traits, including those with logistic curves and those with nonmonotonic curves.
Meanwhile, E -index vector is proposed as well to capture more subtle differences of developmental patterns.
American Psychological Association (APA)
Qi, Jiandong& Sun, Jianfeng& Wang, Jianxin. 2016. E -Index for Differentiating Complex Dynamic Traits. BioMed Research International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1098214
Modern Language Association (MLA)
Qi, Jiandong…[et al.]. E -Index for Differentiating Complex Dynamic Traits. BioMed Research International No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1098214
American Medical Association (AMA)
Qi, Jiandong& Sun, Jianfeng& Wang, Jianxin. E -Index for Differentiating Complex Dynamic Traits. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1098214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098214