Expression Profile of Long Noncoding RNAs in Human Earlobe Keloids: A Microarray Analysis
Joint Authors
Guo, Liang
Xu, Kai
Yan, Hongbo
Feng, Haifeng
Chai, Linlin
Xu, Guozheng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Long noncoding RNAs (lncRNAs) play key roles in a wide range of biological processes and their deregulation results in human disease, including keloids.
Earlobe keloid is a type of pathological skin scar, and the molecular pathogenesis of this disease remains largely unknown.
Methods.
In this study, microarray analysis was used to determine the expression profiles of lncRNAs and mRNAs between 3 pairs of earlobe keloid and normal specimens.
Gene Ontology (GO) categories and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to identify the main functions of the differentially expressed genes and earlobe keloid-related pathways.
Results.
A total of 2068 lncRNAs and 1511 mRNAs were differentially expressed between earlobe keloid and normal tissues.
Among them, 1290 lncRNAs and 1092 mRNAs were upregulated, and 778 lncRNAs and 419 mRNAs were downregulated.
Pathway analysis revealed that 24 pathways were correlated to the upregulated transcripts, while 11 pathways were associated with the downregulated transcripts.
Conclusion.
We characterized the expression profiles of lncRNA and mRNA in earlobe keloids and suggest that lncRNAs may serve as diagnostic biomarkers for the therapy of earlobe keloid.
American Psychological Association (APA)
Guo, Liang& Xu, Kai& Yan, Hongbo& Feng, Haifeng& Chai, Linlin& Xu, Guozheng. 2016. Expression Profile of Long Noncoding RNAs in Human Earlobe Keloids: A Microarray Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098238
Modern Language Association (MLA)
Guo, Liang…[et al.]. Expression Profile of Long Noncoding RNAs in Human Earlobe Keloids: A Microarray Analysis. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098238
American Medical Association (AMA)
Guo, Liang& Xu, Kai& Yan, Hongbo& Feng, Haifeng& Chai, Linlin& Xu, Guozheng. Expression Profile of Long Noncoding RNAs in Human Earlobe Keloids: A Microarray Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098238