Lack of Association between Genetic Polymorphisms of JAK-STAT Signaling Pathway Genes and Acute Anterior Uveitis in Han Chinese
Joint Authors
Cheng, Ling
Yu, Hongsong
Jiang, Yan
He, Juan
Pu, Sisi
Li, Xin
Zhang, Li
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
This study aimed to investigate the association between single nucleotide polymorphisms (SNPs) of JAK-STAT signaling pathway genes and acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS) in the Han Chinese population.
Methods.
Eleven SNPs of the JAK1, JAK2, STAT1, IRF1, and NOS2 genes were analyzed in 443 AAU patients with AS, 486 AAU patients without AS, and 714 healthy controls.
Genotyping was performed by PCR-RFLP assay or TaqMan® probe assay.
The Chi-squared (χ2) test and multivariate logistic regression analysis were used to compare the distributions of alleles and genotypes between patients and controls.
P values were adjusted using Bonferroni correction.
Results.
We did not observe significant differences in the genotype and allele frequencies of any SNP between AAU patients with or without AS and healthy controls.
Stratification analyses by gender and HLA-B27 status showed a boundary significant association between two SNPs (rs10975003 and rs10758669) in JAK2 and AAU (P=0.052 and P=0.053, resp.).
Conclusions.
Our results indicated that genetic polymorphisms of the JAK-STAT signaling pathway genes may not be associated with AAU in the Han Chinese population.
American Psychological Association (APA)
Cheng, Ling& Yu, Hongsong& Jiang, Yan& He, Juan& Pu, Sisi& Li, Xin…[et al.]. 2016. Lack of Association between Genetic Polymorphisms of JAK-STAT Signaling Pathway Genes and Acute Anterior Uveitis in Han Chinese. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098242
Modern Language Association (MLA)
Cheng, Ling…[et al.]. Lack of Association between Genetic Polymorphisms of JAK-STAT Signaling Pathway Genes and Acute Anterior Uveitis in Han Chinese. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098242
American Medical Association (AMA)
Cheng, Ling& Yu, Hongsong& Jiang, Yan& He, Juan& Pu, Sisi& Li, Xin…[et al.]. Lack of Association between Genetic Polymorphisms of JAK-STAT Signaling Pathway Genes and Acute Anterior Uveitis in Han Chinese. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098242