Skeletal Muscle Remodelling as a Function of Disease Progression in Amyotrophic Lateral Sclerosis
Joint Authors
Jensen, L.
Schrøder, H. D.
Frandsen, U.
Jørgensen, L. H.
Bech, R. D.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Muscle weakness is considered the pivotal sign of amyotrophic lateral sclerosis (ALS).
Knowledge about the skeletal muscle degeneration/regeneration process and the myogenic potential is limited in ALS patients.
Therefore, we investigate these processes in a time course perspective by analysing skeletal muscle biopsies from ALS patients collected before and after a 12-week period of normal daily activities and compare these with healthy age-matched control tissue.
We do this by evaluating mRNA and protein (immunohistochemical) markers of regeneration, neurodegeneration, myogenesis, cell cycle regulation, and inflammation.
Our results show morphological changes indicative of active denervation and reinnervation and an increase in small atrophic fibres.
We demonstrate differences between ALS and controls in pathways controlling skeletal muscle homeostasis, cytoskeletal and regenerative markers, neurodegenerative factors, myogenic factors, cell cycle determinants, and inflammatory markers.
Our results on Pax7 and MyoD protein expression suggest that proliferation and differentiation of skeletal muscle stem cells are affected in ALS patients, and the myogenic processes cannot overcome the denervation-induced wasting.
American Psychological Association (APA)
Jensen, L.& Jørgensen, L. H.& Bech, R. D.& Frandsen, U.& Schrøder, H. D.. 2016. Skeletal Muscle Remodelling as a Function of Disease Progression in Amyotrophic Lateral Sclerosis. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098271
Modern Language Association (MLA)
Jensen, L.…[et al.]. Skeletal Muscle Remodelling as a Function of Disease Progression in Amyotrophic Lateral Sclerosis. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1098271
American Medical Association (AMA)
Jensen, L.& Jørgensen, L. H.& Bech, R. D.& Frandsen, U.& Schrøder, H. D.. Skeletal Muscle Remodelling as a Function of Disease Progression in Amyotrophic Lateral Sclerosis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098271