Factors Associated with Missed Detection of Mycobacterium tuberculosis by Automated BACTEC MGIT 960 System
Joint Authors
Pang, Yu
Su, Biyi
Zheng, Huiwen
Zhang, Zhiguo
Ma, Aijing
Wang, Yufeng
Zhao, Yanlin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-19
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Despite the demonstration of excellent performance, mycobacterial growth in BACTEC MGIT 960 can go undetected.
The aim of this study was to investigate the prevalence of “false-negative” culture sample in Beijing and the potential factors associated with the detection failures by MGIT 960.
Of the 577 sputum samples tested, 141 (24.4%) were culture-positive for mycobacteria, of which 133 (94.3%) were automatically determined by MGIT 960 system and 8 (5.7%) were positive for visual growth (false negative by MGIT).
Statistical analysis showed that positive grade of specimen had no influence on the false-negative rate by MGIT 960 system ( χ 2 = 2.207 , P = 0.820 ).
In addition, the mean time to detection (TTD) was 241.4 (range: 224–261) hours for false-negative group and 186.8 (range: 173–199) hours for positive group.
The difference in TTD between false-negative and positive groups was statistically significant ( P < 0.01 ).
In conclusion, our data demonstrate that the automatic MGIT missed a small portion of bacteriological mycobacterial patients.
In addition, the poor growth rate rather than the low grade of AFB smear is associated with the detection failure by MGIT.
Our findings highlight the notion that manual inspection for all instrument-negative MGIT tubes will bring about considerable benefit to patients and clinicians.
American Psychological Association (APA)
Pang, Yu& Su, Biyi& Zheng, Huiwen& Zhang, Zhiguo& Ma, Aijing& Wang, Yufeng…[et al.]. 2016. Factors Associated with Missed Detection of Mycobacterium tuberculosis by Automated BACTEC MGIT 960 System. BioMed Research International،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1098296
Modern Language Association (MLA)
Pang, Yu…[et al.]. Factors Associated with Missed Detection of Mycobacterium tuberculosis by Automated BACTEC MGIT 960 System. BioMed Research International No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1098296
American Medical Association (AMA)
Pang, Yu& Su, Biyi& Zheng, Huiwen& Zhang, Zhiguo& Ma, Aijing& Wang, Yufeng…[et al.]. Factors Associated with Missed Detection of Mycobacterium tuberculosis by Automated BACTEC MGIT 960 System. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1098296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098296