Function, Role, and Clinical Application of MicroRNAs in Vascular Aging
Joint Authors
Tan, Pan
Lin, Xiao
Deng, Hui-Qian
Zhan, Jun-Kun
Chen, Yi-Yin
Liu, You-Shuo
Wang, Yan-Jiao
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-21
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Vascular aging, a specific type of organic aging, is related to age-dependent changes in the vasculature, including atherosclerotic plaques, arterial stiffness, fibrosis, and increased intimal thickening.
Vascular aging could influence the threshold, process, and severity of various cardiovascular diseases, thus making it one of the most important risk factors in the high mortality of cardiovascular diseases.
As endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are the main cell biological basis of these pathology changes of the vasculature, the structure and function of ECs and VSMCs play a key role in vascular aging.
MicroRNAs (miRNAs), small noncoding RNAs, have been shown to regulate the expression of multiple messenger RNAs (mRNAs) posttranscriptionally, contributing to many crucial aspects of cell biology.
Recently, miRNAs with functions associated with aging or aging-related diseases have been studied.
In this review, we will summarize the reported role of miRNAs in the process of vascular aging with special emphasis on EC and VSMC functions.
In addition, the potential application of miRNAs to clinical practice for the diagnosis and treatment of cardiovascular diseases will also be discussed.
American Psychological Association (APA)
Lin, Xiao& Zhan, Jun-Kun& Wang, Yan-Jiao& Tan, Pan& Chen, Yi-Yin& Deng, Hui-Qian…[et al.]. 2016. Function, Role, and Clinical Application of MicroRNAs in Vascular Aging. BioMed Research International،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1098349
Modern Language Association (MLA)
Lin, Xiao…[et al.]. Function, Role, and Clinical Application of MicroRNAs in Vascular Aging. BioMed Research International No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1098349
American Medical Association (AMA)
Lin, Xiao& Zhan, Jun-Kun& Wang, Yan-Jiao& Tan, Pan& Chen, Yi-Yin& Deng, Hui-Qian…[et al.]. Function, Role, and Clinical Application of MicroRNAs in Vascular Aging. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1098349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098349