The Effect of Teriparatide on Fracture Healing of Osteoporotic Patients: A Meta-Analysis of Randomized Controlled Trials
Joint Authors
Tang, Peifu
Zhang, Licheng
Lou, Shenghan
Lv, Houchen
Wang, Guoqi
Li, Ming
Li, Zhirui
Zhang, Lihai
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
This meta-analysis is to assess the effectiveness of teriparatide in fracture healing and clinical function improvement of the osteoporotic patients.
Methods.
We searched PubMed, Embase, Web of Science, and the Cochrane databases for randomized and quasi-randomized controlled trials comparing teriparatide to placebo, no treatment, or comparator interventions in the osteoporotic patients.
Results.
Five studies with 251 patients were included.
Patients treated with teriparatide therapy had a significant shorter radiological fracture healing time compared with those in the control group (mean difference [MD] −4.54 days, 95% confidence interval [CI] −8.80 to −0.28).
Stratified analysis showed that lower limb group had significant shorter healing time (MD −6.24 days, 95% CI −7.20 to −5.29), but upper limb group did not (MD −1 days, 95% CI −2.02 to 0.2).
Patients treated with teriparatide therapy showed better functional outcome than those in the control group (standardized mean difference [SMD] −1.02, 95% CI −1.81 to −0.22).
Patients with therapy duration over 4 weeks would have better functional outcome (SMD −1.68, 95% CI −2.07 to −1.29).
Conclusions.
Teriparatide is effective in accelerating fracture healing and improving functional outcome of osteoporotic women.
However, more clinical studies are warranted in order to determine whether the results are applicable to males and the clinical indications for teriparatide after osteoporotic fractures.
American Psychological Association (APA)
Lou, Shenghan& Lv, Houchen& Wang, Guoqi& Zhang, Licheng& Li, Ming& Li, Zhirui…[et al.]. 2016. The Effect of Teriparatide on Fracture Healing of Osteoporotic Patients: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098352
Modern Language Association (MLA)
Lou, Shenghan…[et al.]. The Effect of Teriparatide on Fracture Healing of Osteoporotic Patients: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1098352
American Medical Association (AMA)
Lou, Shenghan& Lv, Houchen& Wang, Guoqi& Zhang, Licheng& Li, Ming& Li, Zhirui…[et al.]. The Effect of Teriparatide on Fracture Healing of Osteoporotic Patients: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098352