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Kinetics of Cardiac Output at the Onset of Exercise in Precapillary Pulmonary Hypertension
Joint Authors
Lador, Frédéric
Bringard, Aurélien
Bengueddache, Samir
Ferretti, Guido
Soccal, Paola M.
Noble, Stéphane
Beghetti, Maurice
Chemla, Denis
Hervé, Philippe
Sitbon, Olivier
Bendjelid, Karim
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
Cardiac output (CO) is a cornerstone parameter in precapillary pulmonary hypertension (PH).
The Modelflow (MF) method offers a reliable noninvasive determination of its beat-by-beat changes.
So MF allows exploration of CO adjustment with the best temporal resolution.
Methods.
Fifteen subjects (5 PH patients, 10 healthy controls) performed a submaximal supine exercise on a cycle ergometer after 5 min of rest.
CO was continuously determined by MF (COMF).
Kinetics of heart rate (HR), stroke volume (SV), and CO were determined with 3 monoexponential models.
Results.
In PH patients, we observed a sudden and transitory drop of SV upon exercise onset.
This implied a transitory drop of CO whose adjustment to a new steady state depended on HR increase.
The kinetics of HR and CO for PH patients was slower than that of controls for all models and for SV in model 1.
SV kinetics was faster for PH patients in models 2 and 3.
Conclusion.
This is the first description of beat-by-beat cardiovascular adjustments upon exercise onset in PH.
The kinetics of HR and CO appeared slower than those of healthy controls and there was a transitory drop of CO upon exercise onset in PH due to a sudden drop of SV.
American Psychological Association (APA)
Lador, Frédéric& Bringard, Aurélien& Bengueddache, Samir& Ferretti, Guido& Bendjelid, Karim& Soccal, Paola M.…[et al.]. 2016. Kinetics of Cardiac Output at the Onset of Exercise in Precapillary Pulmonary Hypertension. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098355
Modern Language Association (MLA)
Lador, Frédéric…[et al.]. Kinetics of Cardiac Output at the Onset of Exercise in Precapillary Pulmonary Hypertension. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098355
American Medical Association (AMA)
Lador, Frédéric& Bringard, Aurélien& Bengueddache, Samir& Ferretti, Guido& Bendjelid, Karim& Soccal, Paola M.…[et al.]. Kinetics of Cardiac Output at the Onset of Exercise in Precapillary Pulmonary Hypertension. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098355