Network Based Approach in the Establishment of the Relationship between Type 2 Diabetes Mellitus and Its Complications at the Molecular Level Coupled with Molecular Docking Mechanism
Joint Authors
Rampogu, Shailima
Rampogu Lemuel, Mary
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Diabetes mellitus (DM) is one of the major metabolic disorders that is currently threatening the world.
DM is seen associated with obesity and diabetic retinopathy (DR).
In the present paper we tried to evaluate the relationship between the three aliments at the gene level and further performed the molecular docking to identify the common drug for all the three diseases.
We have adopted several software programs such as Phenopedia, VennViewer, and CDOCKER to accomplish the objective.
Our results revealed six genes that commonly associated and are involved in the signalling pathway.
Furthermore, evaluation of common gene association from the selected set of genes projected the presence of SIRT1 in all the three aliments.
Therefore, we targeted protein 4KXQ which was produced from the gene SIRT1 and challenged it with eight phytochemicals, adopting the CDOCKER.
C1 compound has displayed highest -CDOCKER energy and -CDOCKER interaction energy of 43.6905 and 43.3953, respectively.
Therefore, this compound is regarded as the most potential lead molecule.
American Psychological Association (APA)
Rampogu, Shailima& Rampogu Lemuel, Mary. 2016. Network Based Approach in the Establishment of the Relationship between Type 2 Diabetes Mellitus and Its Complications at the Molecular Level Coupled with Molecular Docking Mechanism. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098365
Modern Language Association (MLA)
Rampogu, Shailima& Rampogu Lemuel, Mary. Network Based Approach in the Establishment of the Relationship between Type 2 Diabetes Mellitus and Its Complications at the Molecular Level Coupled with Molecular Docking Mechanism. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1098365
American Medical Association (AMA)
Rampogu, Shailima& Rampogu Lemuel, Mary. Network Based Approach in the Establishment of the Relationship between Type 2 Diabetes Mellitus and Its Complications at the Molecular Level Coupled with Molecular Docking Mechanism. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098365