Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice
Joint Authors
Lu, Guotao
Tong, Zhihui
Ding, Yanbing
Liu, Jinjiao
Pan, Yiyuan
Gao, Lin
Tu, Jianfeng
Wang, Yuhui
Liu, George
Li, Weiqin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aspirin has a clear anti-inflammatory effect and is used as an anti-inflammatory agent for both acute and long-term inflammation.
Previous study has indicated that aspirin alleviated acute pancreatitis induced by caerulein in rat.
However, the role of aspirin on severe acute pancreatitis (SAP) and the necrosis of pancreatic acinar cell are not yet clear.
The aim of this study was to determine the effects of aspirin treatment on a SAP model induced by caerulein combined with Lipopolysaccharide.
We found that aspirin reduced serum amylase and lipase levels, decreased the MPO activity, and alleviated the histopathological manifestations of pancreas and pancreatitis-associated lung injury.
Proinflammatory cytokines were decreased and the expression of NF-κB p65 in acinar cell nuclei was suppressed after aspirin treatment.
Furthermore, aspirin induced the apoptosis of acinar cells by TUNEL assay, and the expression of Bax and caspase 3 was increased and the expression of Bcl-2 was decreased.
Intriguingly, the downregulation of critical necrosis associated proteins RIP1, RIP3, and p-MLKL was observed; what is more, we additionally found that aspirin reduced the COX level of pancreatic tissue.
In conclusion, our data showed that aspirin could protect pancreatic acinar cell against necrosis and reduce the severity of SAP.
Clinically, aspirin may potentially be a therapeutic intervention for SAP.
American Psychological Association (APA)
Lu, Guotao& Tong, Zhihui& Ding, Yanbing& Liu, Jinjiao& Pan, Yiyuan& Gao, Lin…[et al.]. 2016. Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098382
Modern Language Association (MLA)
Lu, Guotao…[et al.]. Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1098382
American Medical Association (AMA)
Lu, Guotao& Tong, Zhihui& Ding, Yanbing& Liu, Jinjiao& Pan, Yiyuan& Gao, Lin…[et al.]. Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098382