Tricellular Tight Junctions in the Inner Ear
Joint Authors
Kitajiri, Shin-ichiro
Katsuno, Tatsuya
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Tight junctions (TJs) are structures that seal the space between the epithelial cell sheets.
In the inner ear, the barrier function of TJs is indispensable for the separation of the endolymphatic and perilymphatic spaces, which is essential for the generation and maintenance of the endocochlear potential (EP).
TJs are formed by the intercellular binding of membrane proteins, known as claudins, and mutations in these proteins cause deafness in humans and mice.
Within the epithelial cell sheet, however, a bound structure is present at the site where the corners of three cells meet (tricellular tight junctions (tTJs)), and the maintenance of the barrier function at this location cannot be explained by the claudins alone.
Tricellulin and the angulin family of proteins (angulin-1/LSR, angulin-2/ILDR1, and angulin-3/ILDR2) have been identified as tTJ-associated proteins.
Tricellulin and ILDR1 are localized at the tTJ and alterations in these proteins have been reported to be involved in deafness.
In this review, we will present the current state of knowledge for tTJs.
American Psychological Association (APA)
Kitajiri, Shin-ichiro& Katsuno, Tatsuya. 2016. Tricellular Tight Junctions in the Inner Ear. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1098398
Modern Language Association (MLA)
Kitajiri, Shin-ichiro& Katsuno, Tatsuya. Tricellular Tight Junctions in the Inner Ear. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1098398
American Medical Association (AMA)
Kitajiri, Shin-ichiro& Katsuno, Tatsuya. Tricellular Tight Junctions in the Inner Ear. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1098398
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098398