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Deregulated Cardiac Specific MicroRNAs in Postnatal Heart Growth
Joint Authors
Yu, Pujiao
Wang, Hongbao
Xie, Yuan
Zhou, Jinzhe
Yao, Jianhua
Che, Lin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The heart is recognized as an organ that is terminally differentiated by adulthood.
However, during the process of human development, the heart is the first organ with function in the embryo and grows rapidly during the postnatal period.
MicroRNAs (miRNAs, miRs), as regulators of gene expression, play important roles during the development of multiple systems.
However, the role of miRNAs in postnatal heart growth is still unclear.
In this study, by using qRT-PCR, we compared the expression of seven cardiac- or muscle-specific miRNAs that may be related to heart development in heart tissue from mice at postnatal days 0, 3, 8, and 14.
Four miRNAs—miR-1a-3p, miR-133b-3p, miR-208b-3p, and miR-206-3p—were significantly decreased while miR-208a-3p was upregulated during the postnatal heart growth period.
Based on these results, GeneSpring GX was used to predict potential downstream targets by performing a 3-way comparison of predictions from the miRWalk, PITA, and microRNAorg databases.
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were used to identify potential functional annotations and signaling pathways related to postnatal heart growth.
This study describes expression changes of cardiac- and muscle-specific miRNAs during postnatal heart growth and may provide new therapeutic targets for cardiovascular diseases.
American Psychological Association (APA)
Yu, Pujiao& Wang, Hongbao& Xie, Yuan& Zhou, Jinzhe& Yao, Jianhua& Che, Lin. 2016. Deregulated Cardiac Specific MicroRNAs in Postnatal Heart Growth. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098418
Modern Language Association (MLA)
Yu, Pujiao…[et al.]. Deregulated Cardiac Specific MicroRNAs in Postnatal Heart Growth. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1098418
American Medical Association (AMA)
Yu, Pujiao& Wang, Hongbao& Xie, Yuan& Zhou, Jinzhe& Yao, Jianhua& Che, Lin. Deregulated Cardiac Specific MicroRNAs in Postnatal Heart Growth. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098418