Osteopontin Promotes Expression of Matrix Metalloproteinase 13 through NF-κB Signaling in Osteoarthritis
Joint Authors
Li, Yusheng
Jiang, Wei
Wang, Hua
Deng, Zhenhan
Zeng, Chao
Tu, Min
Li, Liangjun
Xiao, Wenfeng
Gao, Shuguang
Luo, Wei
Lei, Guanghua
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Osteopontin (OPN) is associated with the severity and progression of osteoarthritis (OA); however, the mechanism of OPN in the pathogenesis of OA is unknown.
In this study, we found that OA patients had higher abundance of OPN and matrix metalloproteinase 13 (MMP13).
In chondrocytes, we showed that OPN promoted the production of MMP13 and activation of NF- κ B pathway by increasing the abundance of p65 and phosphorylated p65 and translocation of p65 protein from cytoplasm to nucleus.
Notably, inhibition of NF- κ B pathway by inhibitor suppressed the production of MMP13 induced by OPN treatment.
In conclusion, OPN induces production of MMP13 through activation of NF- κ B pathway.
American Psychological Association (APA)
Li, Yusheng& Jiang, Wei& Wang, Hua& Deng, Zhenhan& Zeng, Chao& Tu, Min…[et al.]. 2016. Osteopontin Promotes Expression of Matrix Metalloproteinase 13 through NF-κB Signaling in Osteoarthritis. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098440
Modern Language Association (MLA)
Li, Yusheng…[et al.]. Osteopontin Promotes Expression of Matrix Metalloproteinase 13 through NF-κB Signaling in Osteoarthritis. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098440
American Medical Association (AMA)
Li, Yusheng& Jiang, Wei& Wang, Hua& Deng, Zhenhan& Zeng, Chao& Tu, Min…[et al.]. Osteopontin Promotes Expression of Matrix Metalloproteinase 13 through NF-κB Signaling in Osteoarthritis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098440