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The Role of Interleukin-18 in Serum and Follicular Fluid during In Vitro Fertilization and Intracytoplasmic Sperm Injection
Joint Authors
Alkatout, Ibrahim
Fuhs, Corinna
Salmassi, Ali
Hedderich, Jürgen
Maass, Nicolai
Elessawy, Mohamed
Schmutzler, Andreas Gerd
Eckmann-Scholz, Christel
Günther, Veronika
Mettler, Liselotte
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cytokines are key modulators of the immune system and play an important role in the ovarian cycle.
IL-18 levels in serum and follicular fluid were analyzed in women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment.
The cohort study group consisted of 90 women, who were undergoing IVF or ICSI.
The body mass index (BMI) was determined in all patients; IL-18 levels were measured in follicular fluid and serum.
IL-18 levels in serum were significantly higher than those in follicular fluid.
The median level in serum was 162.75 (80.21) pg/mL and that in follicular fluid, 138.24 (91.78) pg/mL.
Women undergoing IVF treatment had lower IL-18 levels in serum (median, 151.19 (90.73) pg/mL) than those treated with ICSI (median, 163.57 (89.97) pg/mL).
The correlation between IL-18 levels in serum and BMI was statistically significant, as well as the correlation between IL-18 levels in follicular fluid and ovarian stimulation response ( p = 0.003 ).
IL-18 was correlated with the response to ovarian stimulation and was the reason for successful pregnancy after IVF or ICSI treatment.
Among other cytokines, IL-18 appears to be a promising prognostic marker of success in reproductive treatment and should be evaluated as such in further prospective studies.
American Psychological Association (APA)
Günther, Veronika& Alkatout, Ibrahim& Fuhs, Corinna& Salmassi, Ali& Mettler, Liselotte& Hedderich, Jürgen…[et al.]. 2016. The Role of Interleukin-18 in Serum and Follicular Fluid during In Vitro Fertilization and Intracytoplasmic Sperm Injection. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098444
Modern Language Association (MLA)
Günther, Veronika…[et al.]. The Role of Interleukin-18 in Serum and Follicular Fluid during In Vitro Fertilization and Intracytoplasmic Sperm Injection. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098444
American Medical Association (AMA)
Günther, Veronika& Alkatout, Ibrahim& Fuhs, Corinna& Salmassi, Ali& Mettler, Liselotte& Hedderich, Jürgen…[et al.]. The Role of Interleukin-18 in Serum and Follicular Fluid during In Vitro Fertilization and Intracytoplasmic Sperm Injection. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098444