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Acute Aortic Dissection Biomarkers Identified Using Isobaric Tags for Relative and Absolute Quantitation
Joint Authors
Xiao, Ziya
Xue, Yuan
Zhang, Yaping
Zhang, Jin
Fan, Fan
Luan, Xiao
Deng, Zhi
Tao, Zhengang
Song, Zhen-ju
Wang, Haojun
Yao, Chenling
Tong, Chaoyang
Gu, Guorong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The purpose of this study was to evaluate the utility of potential serum biomarkers for acute aortic dissection (AAD) that were identified by isobaric Tags for Relative and Absolute Quantitation (iTRAQ) approaches.
Serum samples from 20 AAD patients and 20 healthy volunteers were analyzed using iTRAQ technology.
Protein validation was performed using samples from 120 patients with chest pain.
A total of 355 proteins were identified with the iTRAQ approach; 164 proteins reached the strict quantitative standard, and 125 proteins were increased or decreased more than 1.2-fold (64 and 61 proteins were up- and downregulated, resp.).
Lumican, C-reactive protein (CRP), thrombospondin-1 (TSP-1), and D-dimer were selected as candidate biomarkers for the validation tests.
Receiver operating characteristic (ROC) curves show that Lumican and D-dimer have diagnostic value (area under the curves [AUCs] 0.895 and 0.891, P < 0.05 ).
For Lumican, the diagnostic sensitivity and specificity were 73.33% and 98.33%, while the corresponding values for D-dimer were 93.33% and 68.33%.
For Lumican and D-dimer AAD combined diagnosis, the sensitivity and specificity were 88.33% and 95%, respectively.
In conclusion, Lumican has good specificity and D-dimer has good sensitivity for the diagnosis of AAD, while the combined detection of D-dimer and Lumican has better diagnostic value.
American Psychological Association (APA)
Xiao, Ziya& Xue, Yuan& Yao, Chenling& Gu, Guorong& Zhang, Yaping& Zhang, Jin…[et al.]. 2016. Acute Aortic Dissection Biomarkers Identified Using Isobaric Tags for Relative and Absolute Quantitation. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098471
Modern Language Association (MLA)
Xiao, Ziya…[et al.]. Acute Aortic Dissection Biomarkers Identified Using Isobaric Tags for Relative and Absolute Quantitation. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098471
American Medical Association (AMA)
Xiao, Ziya& Xue, Yuan& Yao, Chenling& Gu, Guorong& Zhang, Yaping& Zhang, Jin…[et al.]. Acute Aortic Dissection Biomarkers Identified Using Isobaric Tags for Relative and Absolute Quantitation. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098471