Predictors of Survival in Esophageal Squamous Cell Carcinoma with Pathologic Major Response after Neoadjuvant Chemoradiation Therapy and Surgery: The Impact of Chemotherapy Protocols
Joint Authors
Li, Chia-Ying
Huang, Pei-Ming
Chu, Pei-Yi
Chen, Po-Ming
Lin, Mong-Wei
Kuo, Shuenn-Wen
Lee, Jang-Ming
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tumor recurrence is an important problem threatening esophageal cancer patients after surgery, even when they achieve a pathologic major response (pMR) after neoadjuvant concurrent chemoradiation therapy (CCRT).
The predictors related to overall survival and disease progression for these patients remain elusive.
We aimed to identify factors that predict disease progression and overall survival in esophageal squamous cell carcinoma (SCC) patients who achieve a pMR after neoadjuvant CCRT followed by surgery.
We conducted a retrospective study to analyze the factors influencing survival and disease progression after esophagectomy for esophageal cancer patients who had a major response to CCRT, which is defined by complete pathological response or microscopic residual disease without lymph node metastasis.
From our study cohort, 285 patients underwent CCRT and subsequent esophagectomy; 171 (60%) of these patients achieved pMR.
After excluding patients with lymph node metastases, incomplete clinical data, and adenocarcinomas, we enrolled 117 patients in this study.
We found that the CCRT regimen was the only factor that influenced overall survival.
The overall survival of the patients receiving taxane-incorporated CCRT was superior to that of patients receiving traditional cisplatin and 5-fluorouracil (PF) ( P = 0.01 1 ).
The CCRT regimen can significantly influence the clinical outcome of esophageal SCC patients who achieve pMR after neoadjuvant CCRT and esophagectomy.
Incorporation of taxanes into cisplatin-based CCRT may be associated with prolonged survival.
American Psychological Association (APA)
Li, Chia-Ying& Huang, Pei-Ming& Chu, Pei-Yi& Chen, Po-Ming& Lin, Mong-Wei& Kuo, Shuenn-Wen…[et al.]. 2016. Predictors of Survival in Esophageal Squamous Cell Carcinoma with Pathologic Major Response after Neoadjuvant Chemoradiation Therapy and Surgery: The Impact of Chemotherapy Protocols. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098472
Modern Language Association (MLA)
Li, Chia-Ying…[et al.]. Predictors of Survival in Esophageal Squamous Cell Carcinoma with Pathologic Major Response after Neoadjuvant Chemoradiation Therapy and Surgery: The Impact of Chemotherapy Protocols. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098472
American Medical Association (AMA)
Li, Chia-Ying& Huang, Pei-Ming& Chu, Pei-Yi& Chen, Po-Ming& Lin, Mong-Wei& Kuo, Shuenn-Wen…[et al.]. Predictors of Survival in Esophageal Squamous Cell Carcinoma with Pathologic Major Response after Neoadjuvant Chemoradiation Therapy and Surgery: The Impact of Chemotherapy Protocols. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098472
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098472