Cone Beam X-Ray Luminescence Tomography Imaging Based on KA-FEM Method for Small Animals

Abstract EN

Cone beam X-ray luminescence tomography can realize fast X-ray luminescence tomography imaging with relatively low scanning time compared with narrow beam X-ray luminescence tomography.

However, cone beam X-ray luminescence tomography suffers from an ill-posed reconstruction problem.

First, the feasibility of experiments with different penetration and multispectra in small animal has been tested using nanophosphor material.

Then, the hybrid reconstruction algorithm with KA-FEM method has been applied in cone beam X-ray luminescence tomography for small animals to overcome the ill-posed reconstruction problem, whose advantage and property have been demonstrated in fluorescence tomography imaging.

The in vivo mouse experiment proved the feasibility of the proposed method.