Changes in Serum Concentrations of Fibroblast Growth Factor 23 and Soluble Klotho in Hemodialysis Patients after Total Parathyroidectomy
Joint Authors
Liao, Shang-Chih
Moi, Sin-Hua
Chou, Fong-Fu
Chen, Jin-Bor
Yang, Cheng-Hong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
We examined the changes in circulating fibroblast growth factor 23 (FGF23) and Klotho concentrations in hemodialysis patients after parathyroidectomy (PTX).
Methods.
We enrolled a cohort of hemodialysis patients who received PTX.
Postoperatively, patients received calcium supplements and/or vitamin D analogue (calcitriol) to maintain serum calcium within 7.0–8.0 mg/dL.
Information on clinical parameters including bone-mineral metabolic variables was collected pre-PTX and on days 5 and 90 after PTX.
Concomitantly, serum full-length FGF23 and α-Klotho levels were measured.
The relationship between FGF23 and clinical parameters was analyzed by single linear regression.
Results.
Forty-six participants (33 women; 13 men) were enrolled in the study.
Their mean age was 56.49 years.
Serum FGF23 and α-Klotho concentrations were elevated on days 5 and 90 after PTX compared to baseline (p>0.05).
Serum FGF23 concentrations negatively correlated with serum calcium concentrations pre-PTX (Beta -0.31; R2 0.0949; p=0.040), day 5 post-PTX (Beta -0.31; R2 0.0982; p=0.036), and day 90 post-PTX (Beta -0.39; R2 0.1528; p=0.008).
Conclusions.
There was no change in circulating FGF23 and Klotho concentrations after PTX in hemodialysis patients given postoperative calcium supplements and/or vitamin D analogue.
Serum FGF23 concentrations pre-PTX and at days 5 and 90 after PTX were inversely related to serum calcium concentrations.
American Psychological Association (APA)
Liao, Shang-Chih& Moi, Sin-Hua& Chou, Fong-Fu& Yang, Cheng-Hong& Chen, Jin-Bor. 2016. Changes in Serum Concentrations of Fibroblast Growth Factor 23 and Soluble Klotho in Hemodialysis Patients after Total Parathyroidectomy. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098491
Modern Language Association (MLA)
Liao, Shang-Chih…[et al.]. Changes in Serum Concentrations of Fibroblast Growth Factor 23 and Soluble Klotho in Hemodialysis Patients after Total Parathyroidectomy. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1098491
American Medical Association (AMA)
Liao, Shang-Chih& Moi, Sin-Hua& Chou, Fong-Fu& Yang, Cheng-Hong& Chen, Jin-Bor. Changes in Serum Concentrations of Fibroblast Growth Factor 23 and Soluble Klotho in Hemodialysis Patients after Total Parathyroidectomy. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098491