![](/images/graphics-bg.png)
MicroRNAs: Novel Crossroads between Myeloma Cells and the Bone Marrow Microenvironment
Joint Authors
Tagliaferri, Pierosandro
Amodio, Nicola
Raimondi, Lavinia
De Luca, Angela
Morelli, Eugenio
Giavaresi, Gianluca
Tassone, Pierfrancesco
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Multiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulate in the bone marrow, where a complex microenvironment made by different cell types supports proliferation, survival, and drug resistance of tumor cells.
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at posttranscriptional level.
Emerging evidence indicates that miRNAs are aberrantly expressed or functionally deregulated in MM cells as the result of multiple genetic or epigenetic mechanisms and that also the tumor microenvironment regulates MM cell functions by miRNAs.
Consistently, modulation of miRNA levels in MM cells has been demonstrated to impair their functional interaction with the bone marrow microenvironment and to produce significant antitumor activity even able to overcome the protective bone marrow milieu.
This review will describe the most recent findings on miRNA function in the context of MM bone marrow microenvironment, focusing on the therapeutic potential of miRNA-based approaches.
American Psychological Association (APA)
Raimondi, Lavinia& De Luca, Angela& Morelli, Eugenio& Giavaresi, Gianluca& Tagliaferri, Pierosandro& Tassone, Pierfrancesco…[et al.]. 2016. MicroRNAs: Novel Crossroads between Myeloma Cells and the Bone Marrow Microenvironment. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098502
Modern Language Association (MLA)
Raimondi, Lavinia…[et al.]. MicroRNAs: Novel Crossroads between Myeloma Cells and the Bone Marrow Microenvironment. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1098502
American Medical Association (AMA)
Raimondi, Lavinia& De Luca, Angela& Morelli, Eugenio& Giavaresi, Gianluca& Tagliaferri, Pierosandro& Tassone, Pierfrancesco…[et al.]. MicroRNAs: Novel Crossroads between Myeloma Cells and the Bone Marrow Microenvironment. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098502