Edited Magnetic Resonance Spectroscopy Detects an Age-Related Decline in Nonhuman Primate Brain GABA Levels
Joint Authors
He, Xuanzi
Koo, Bang-Bon
Killiany, Ronald J.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Recent research had shown a correlation between aging and decreasing Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain.
However, how GABA level varies with age in the medial portion of the brain has not yet been studied.
The purpose of this study was to investigate the GABA level variation with age focusing on the posterior cingulate cortex, which is the “core hub” of the default mode network.
In this study, 14 monkeys between 4 and 21 years were recruited, and MEGA-PRESS MRS was performed to measure GABA levels, in order to explore a potential link between aging and GABA.
Our results showed that a correlation between age and GABA+/Creatine ratio was at the edge of significance ( r = - 0.523 , p = 0.081 ).
There was also a near-significant trend between gray matter/white matter ratio and the GABA+/Creatine ratio ( r = - 0.518 , p = 0.0848 ).
Meanwhile, the correlation between age and grey matter showed no significance ( r = - 0.028 , p = 0.93 ).
Therefore, age and gray matter/white matter ratio account for different part of R -squared (adjusted R -squared = 0.5187) as independent variables for predicting GABA levels.
Adjusted R -squared is about 0.5 for two independent variables.
These findings suggest that there is internal neurochemical variation of GABA levels in the nonhuman primates associated with normal aging and structural brain decline.
American Psychological Association (APA)
He, Xuanzi& Koo, Bang-Bon& Killiany, Ronald J.. 2016. Edited Magnetic Resonance Spectroscopy Detects an Age-Related Decline in Nonhuman Primate Brain GABA Levels. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098508
Modern Language Association (MLA)
He, Xuanzi…[et al.]. Edited Magnetic Resonance Spectroscopy Detects an Age-Related Decline in Nonhuman Primate Brain GABA Levels. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098508
American Medical Association (AMA)
He, Xuanzi& Koo, Bang-Bon& Killiany, Ronald J.. Edited Magnetic Resonance Spectroscopy Detects an Age-Related Decline in Nonhuman Primate Brain GABA Levels. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098508