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Intracellular Calcium Dysregulation: Implications for Alzheimer’s Disease
Joint Authors
Gratteri, Santo
Magi, Simona
Castaldo, Pasqualina
Macrì, Maria Loredana
Maiolino, Marta
Matteucci, Alessandra
Bastioli, Guendalina
Amoroso, Salvatore
Lariccia, Vincenzo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-02
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by progressive neuronal loss.
AD is associated with aberrant processing of the amyloid precursor protein, which leads to the deposition of amyloid-β plaques within the brain.
Together with plaques deposition, the hyperphosphorylation of the microtubules associated protein tau and the formation of intraneuronal neurofibrillary tangles are a typical neuropathological feature in AD brains.
Cellular dysfunctions involving specific subcellular compartments, such as mitochondria and endoplasmic reticulum (ER), are emerging as crucial players in the pathogenesis of AD, as well as increased oxidative stress and dysregulation of calcium homeostasis.
Specifically, dysregulation of intracellular calcium homeostasis has been suggested as a common proximal cause of neural dysfunction in AD.
Aberrant calcium signaling has been considered a phenomenon mainly related to the dysfunction of intracellular calcium stores, which can occur in both neuronal and nonneuronal cells.
This review reports the most recent findings on cellular mechanisms involved in the pathogenesis of AD, with main focus on the control of calcium homeostasis at both cytosolic and mitochondrial level.
American Psychological Association (APA)
Magi, Simona& Castaldo, Pasqualina& Macrì, Maria Loredana& Maiolino, Marta& Matteucci, Alessandra& Bastioli, Guendalina…[et al.]. 2016. Intracellular Calcium Dysregulation: Implications for Alzheimer’s Disease. BioMed Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1098524
Modern Language Association (MLA)
Magi, Simona…[et al.]. Intracellular Calcium Dysregulation: Implications for Alzheimer’s Disease. BioMed Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1098524
American Medical Association (AMA)
Magi, Simona& Castaldo, Pasqualina& Macrì, Maria Loredana& Maiolino, Marta& Matteucci, Alessandra& Bastioli, Guendalina…[et al.]. Intracellular Calcium Dysregulation: Implications for Alzheimer’s Disease. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1098524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098524