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Targeting Lung Cancer Stem Cells with Antipsychological Drug Thioridazine
Joint Authors
Yue, Haiying
Huang, Dongning
Qin, Li
Zheng, Zhiyong
Hua, Li
Wang, Guodong
Huang, Jian
Huang, Haixin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Lung cancer stem cells are a subpopulation of cells critical for lung cancer progression, metastasis, and drug resistance.
Thioridazine, a classical neurological drug, has been reported with anticancer ability.
However, whether thioridazine could inhibit lung cancer stem cells has never been studied.
In our current work, we used different dosage of thioridazine to test its effect on lung cancer stem cells sphere formation.
The response of lung cancer stem cells to chemotherapy drug with thioridazine treatment was measured.
The cell cycle distribution of lung cancer stem cells after thioridazine treatment was detected.
The in vivo inhibitory effect of thioridazine was also measured.
We found that thioridazine could dramatically inhibit sphere formation of lung cancer stem cells.
It sensitized the LCSCs to chemotherapeutic drugs 5-FU and cisplatin.
Thioridazine altered the cell cycle distribution of LCSCs and decreased the proportion of G0 phase cells in lung cancer stem cells.
Thioridazine inhibited lung cancer stem cells initiated tumors growth in vivo.
This study showed that thioridazine could inhibit lung cancer stem cells in vitro and in vivo.
It provides a potential drug for lung cancer therapy through targeting lung cancer stem cells.
American Psychological Association (APA)
Yue, Haiying& Huang, Dongning& Qin, Li& Zheng, Zhiyong& Hua, Li& Wang, Guodong…[et al.]. 2016. Targeting Lung Cancer Stem Cells with Antipsychological Drug Thioridazine. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098527
Modern Language Association (MLA)
Yue, Haiying…[et al.]. Targeting Lung Cancer Stem Cells with Antipsychological Drug Thioridazine. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098527
American Medical Association (AMA)
Yue, Haiying& Huang, Dongning& Qin, Li& Zheng, Zhiyong& Hua, Li& Wang, Guodong…[et al.]. Targeting Lung Cancer Stem Cells with Antipsychological Drug Thioridazine. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098527