Efficacy Comparison of Tenofovir and Entecavir in HBeAg-Positive Chronic Hepatitis B Patients with High HBV DNA
Joint Authors
Huang, Mingxing
Shi, Hong
Lin, Guoli
Li, Xiangyong
Wu, Yuankai
Jie, Yusheng
Chong, Yutian
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
To compare entecavir (ETV) and tenofovir disoproxil fumarate (TDF) effects in chronic hepatitis B (CHB) patients with high HBV DNA.
Method.
96 patients treated initially with tenofovir (TDF group) or entecavir (ETV group) were included in this retrospective study.
The following parameters were assessed: HBeAg and hepatitis B e antibody (anti-HBe) status, serum alanine aminotransferase (ALT), and HBV-DNA levels at weeks 4, 12, 24, 36, 48, 60, 72, and 96; time to ALT normalization, undetectable HBV-DNA levels, and HBeAg seroconversion; total duration of follow-up and adverse reactions.
Results.
The patients included 66 (69%) and 30 (31%) individuals administered ETV and TDF, respectively, comprising 75% males.
They were 35.1 ± 4.5 and 33.7 ± 4.6 years old in ETV and TDF groups, respectively.
At 36 weeks, the response rate was significantly higher in the TDF group than in ETV treated patients (90% versus 69.7%, p = 0.03 ).
At 48 weeks, less patients administered ETV showed undetectable HBV-DNA levels compared with the TDF group (86.4% versus 96.7%), a non-statistically significant difference ( p = 0.13 ).
Only 1 ETV treated patient developed virological breakthrough at 48–96 w.
No adverse reactions were found.
Conclusion.
ETV and TDF are comparable in efficacy and safety to suppress HBV-DNA replication in HBeAg-positive CHB patients with high HBV DNA.
American Psychological Association (APA)
Shi, Hong& Huang, Mingxing& Lin, Guoli& Li, Xiangyong& Wu, Yuankai& Jie, Yusheng…[et al.]. 2016. Efficacy Comparison of Tenofovir and Entecavir in HBeAg-Positive Chronic Hepatitis B Patients with High HBV DNA. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098531
Modern Language Association (MLA)
Shi, Hong…[et al.]. Efficacy Comparison of Tenofovir and Entecavir in HBeAg-Positive Chronic Hepatitis B Patients with High HBV DNA. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1098531
American Medical Association (AMA)
Shi, Hong& Huang, Mingxing& Lin, Guoli& Li, Xiangyong& Wu, Yuankai& Jie, Yusheng…[et al.]. Efficacy Comparison of Tenofovir and Entecavir in HBeAg-Positive Chronic Hepatitis B Patients with High HBV DNA. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098531