Reproductive Toxicities Caused by Swainsonine from Locoweed in Mice
Joint Authors
Wu, Chenchen
Feng, Ke
Lu, Dezhang
Yan, Dujian
Han, Tiesuo
Zhao, Baoyu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Swainsonine is the primary toxin in locoweeds.
It causes intention tremors, reproductive dysfunction, emaciation, and death.
The objective of the present study was to evaluate the potential reproductive and developmental toxicities caused by swainsonine in mice.
The treatment groups consisting of three generations of mice were given a range of concentrations of swainsonine by intraperitoneal injection (2.50 mg/kg body weight (BW), 1.20 mg/kg BW, 0.60 mg/kg BW, and 0 mg/kg BW).
The 0 mg/kg BW group exhibited significantly fewer estrous cycles and an increased number of estrous ones compared to the 2.50 mg/kg BW, 1.20 mg/kg BW, and 0.60 mg/kg BW groups (P<0.05).
All three generations of mice treated with swainsonine had significantly higher spleen, liver, and kidney indices and significantly lower body weights compared to the 0 mg/kg BW group (P<0.05).
For the first and second generations of treatment group, the copulation indices and the numbers of live pups on postnatal days (PND) 0, 4, and 15 were significantly decreased compared to those of the 0 mg/kg BW group (P<0.05).
The fertility and gestation indices of the treatment group of the first generation were significantly increased compared to the 2.50 mg/kg BW, 1.20 mg/kg BW, and 0.60 mg/kg BW groups of the second generation (P<0.05).
Cumulatively, these results indicate that swainsonine may cause reproductive and developmental toxicities in mice in both parents and offspring.
American Psychological Association (APA)
Wu, Chenchen& Feng, Ke& Lu, Dezhang& Yan, Dujian& Han, Tiesuo& Zhao, Baoyu. 2016. Reproductive Toxicities Caused by Swainsonine from Locoweed in Mice. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098593
Modern Language Association (MLA)
Wu, Chenchen…[et al.]. Reproductive Toxicities Caused by Swainsonine from Locoweed in Mice. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098593
American Medical Association (AMA)
Wu, Chenchen& Feng, Ke& Lu, Dezhang& Yan, Dujian& Han, Tiesuo& Zhao, Baoyu. Reproductive Toxicities Caused by Swainsonine from Locoweed in Mice. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098593