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Interaction Effects between Organochlorine Pesticides and Isoflavones In Vitro and In Vivo
Joint Authors
Zhang, Yunbo
Guo, Jipeng
Zhang, Xiao
Guo, Jingjing
Zhang, Ming
Yang, Yang
Na, Xiaolin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Organochlorine pesticides (OCPs) have caused increasing global concern due to their high toxicity, persistence, bioaccumulation, and significant adverse effects on human health.
This study was to explore the interaction effects between OCPs and isoflavones.
Six kinds of OCPs and 2 kinds of isoflavones-genistein and daidzein were included to study their effect on MCF-7 cells in vitro.
Eighty-one female Sprague-Dawley rats were randomized to 9 groups according to factorial design to study the interaction effect between isoflavones and γ-HCH.
Compared to organochlorine pesticides alone group, proliferation rate of MCF-7 cells was lower in 100 μmol/L genistein + organochlorine pesticides and 100 μmol/L daidzein + organochlorine pesticides group ( p < 0.05 ).
In vivo study showed that there are interaction effects on kidney weight and liver weight when treated with isoflavones and γ-HCH.
The changes in uterine morphology and positive expression of ERα showed inhibition effects between isoflavones and γ-HCH.
In conclusion, the data suggests that there are interactions between isoflavones and OCPs in vitro and in vivo.
American Psychological Association (APA)
Zhang, Yunbo& Guo, Jipeng& Zhang, Xiao& Guo, Jingjing& Zhang, Ming& Yang, Yang…[et al.]. 2016. Interaction Effects between Organochlorine Pesticides and Isoflavones In Vitro and In Vivo. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098612
Modern Language Association (MLA)
Zhang, Yunbo…[et al.]. Interaction Effects between Organochlorine Pesticides and Isoflavones In Vitro and In Vivo. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098612
American Medical Association (AMA)
Zhang, Yunbo& Guo, Jipeng& Zhang, Xiao& Guo, Jingjing& Zhang, Ming& Yang, Yang…[et al.]. Interaction Effects between Organochlorine Pesticides and Isoflavones In Vitro and In Vivo. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098612