Psoralen and Isopsoralen Ameliorate Sex Hormone Deficiency-Induced Osteoporosis in Female and Male Mice
Joint Authors
Yuan, Xiaomei
Bi, Yanan
Yan, Zeman
Pu, Weiling
Li, Yuhong
Zhou, Kun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Osteoporosis is a systemic skeletal disease, which is characterized by a systemic destruction of bone mass and microarchitecture.
With life standard improved, the treatment of osteoporosis attracted more attention.
The aim of this study is to verify the osteoprotective effect of psoralen and isopsoralen in females and males.
Female and male mice were divided into 7 groups in this study: control group (sham-operation), model group (by ovariectomy or orchidectomy), positive control group (females given estradiol valerate; males given alendronate sodium), psoralen groups (10 mg/kg and 20 mg/kg), and isopsoralen groups (10 mg/kg and 20 mg/kg).
After administration of psoralen and isopsoralen for 8 weeks, osteoporosis was ameliorated with increasing bone strength and improving trabecular bone microstructure as indicated by CT scan and pathology.
Serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRACP), osteocalcin (OC), and C-terminal cross-linking telopeptides of type I collagen (CTX-1) were examined.
Decreased TRACP and increased ALP/TRACP suggested restoring from bone destruction.
These results suggest that psoralen and isopsoralen may be used as good natural compounds for the treatment of osteoporosis in males, as well as females.
American Psychological Association (APA)
Yuan, Xiaomei& Bi, Yanan& Yan, Zeman& Pu, Weiling& Li, Yuhong& Zhou, Kun. 2016. Psoralen and Isopsoralen Ameliorate Sex Hormone Deficiency-Induced Osteoporosis in Female and Male Mice. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098614
Modern Language Association (MLA)
Yuan, Xiaomei…[et al.]. Psoralen and Isopsoralen Ameliorate Sex Hormone Deficiency-Induced Osteoporosis in Female and Male Mice. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098614
American Medical Association (AMA)
Yuan, Xiaomei& Bi, Yanan& Yan, Zeman& Pu, Weiling& Li, Yuhong& Zhou, Kun. Psoralen and Isopsoralen Ameliorate Sex Hormone Deficiency-Induced Osteoporosis in Female and Male Mice. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098614