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Predictive Biomarkers in Colorectal Cancer: From the Single Therapeutic Target to a Plethora of Options
Joint Authors
Martins, Sandra F.
Rodrigues, Daniela
Longatto-Filho, Adhemar
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Colorectal cancer (CRC) is one of the most frequent cancers and is a leading cause of cancer death worldwide.
Treatments used for CRC may include some combination of surgery, radiation therapy, chemotherapy, and targeted therapy.
The current standard drugs used in chemotherapy are 5-fluorouracil and leucovorin in combination with irinotecan and/or oxaliplatin.
Most recently, biologic agents have been proven to have therapeutic benefits in metastatic CRC alone or in association with standard chemotherapy.
However, patients present different treatment responses, in terms of efficacy and toxicity; therefore, it is important to identify biological markers that can predict the response to therapy and help select patients that would benefit from specific regimens.
In this paper, authors review CRC genetic markers that could be useful in predicting the sensitivity/resistance to chemotherapy.
American Psychological Association (APA)
Rodrigues, Daniela& Longatto-Filho, Adhemar& Martins, Sandra F.. 2016. Predictive Biomarkers in Colorectal Cancer: From the Single Therapeutic Target to a Plethora of Options. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098624
Modern Language Association (MLA)
Rodrigues, Daniela…[et al.]. Predictive Biomarkers in Colorectal Cancer: From the Single Therapeutic Target to a Plethora of Options. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1098624
American Medical Association (AMA)
Rodrigues, Daniela& Longatto-Filho, Adhemar& Martins, Sandra F.. Predictive Biomarkers in Colorectal Cancer: From the Single Therapeutic Target to a Plethora of Options. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098624