Development of a New Hybrid Biodegradable Drug-Eluting Stent for the Treatment of Peripheral Artery Disease
Joint Authors
Ko, Young-Guk
Jang, Yangsoo
Hong, Myeong-Ki
Lee, Jung-Hee
Kim, Soon-Joong
Park, Se-Il
Choi, Dong Hoon
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility.
All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitinol.
Four different types of stents were implanted in 20 iliac arteries in 10 mini pigs as follows: a bare-metal stent (BMS) (group 1, n=5), a drug-free hybrid stent (group 2, n=5), a 50% (50 : 100, w/w) paclitaxel (PTX)/poly-lactide-co-glycolic acid (PLGA; fast PTX-releasing form) hybrid stent (group 3, n=5), and a 30% (30 : 100, w/w) PTX/PLGA (slow PTX-releasing form) hybrid stent (group 4, n=5).
We performed follow-up angiography and intravascular ultrasonography (IVUS) at 4 and 8 weeks.
In a comparison of groups 1, 2, 3, and 4, less diameter stenosis was observed in the angiographic analysis for group 4 at the 4-week follow-up (19.0% ± 12.7% versus 39.3% ± 18.1% versus 46.8% ± 38.0% versus 4.8% ± 4.2%, resp.; p=0.032).
IVUS findings further suggested that the neointima of the patients in group 4 tended to be lesser than those of the others.
Our new biodegradable 30% PTX/PLGA (slow-releasing form) stent showed more favorable results for patency than the other stent types.
American Psychological Association (APA)
Lee, Jung-Hee& Kim, Soon-Joong& Park, Se-Il& Ko, Young-Guk& Choi, Dong Hoon& Hong, Myeong-Ki…[et al.]. 2016. Development of a New Hybrid Biodegradable Drug-Eluting Stent for the Treatment of Peripheral Artery Disease. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098628
Modern Language Association (MLA)
Lee, Jung-Hee…[et al.]. Development of a New Hybrid Biodegradable Drug-Eluting Stent for the Treatment of Peripheral Artery Disease. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098628
American Medical Association (AMA)
Lee, Jung-Hee& Kim, Soon-Joong& Park, Se-Il& Ko, Young-Guk& Choi, Dong Hoon& Hong, Myeong-Ki…[et al.]. Development of a New Hybrid Biodegradable Drug-Eluting Stent for the Treatment of Peripheral Artery Disease. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098628