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Serum Cytokine Responses over the Entire Clinical-Immunological Spectrum of Human Leishmania (L.) infantum chagasi Infection
Joint Authors
Corbett, Carlos E. P.
Gomes, Claudia Maria de Castro
Ramos, Patrícia Karla
Carvalho, Karina Inácio
Rosa, Daniela Santoro
Rodrigues, Ana Paula
Lima, Luciana Vieira
Campos, Marliane Batista
Laurenti, Márcia Dalastra
Silveira, Fernando Tobias
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi infection in Amazonian Brazil was recently reviewed based on clinical, DTH, and IFAT (IgG) evaluations that identified five profiles: three asymptomatic (asymptomatic infection, AI; subclinical resistant infection, SRI; and indeterminate initial infection, III) and two symptomatic (symptomatic infection, SI; American visceral leishmaniasis, AVL; and subclinical oligosymptomatic infection, SOI).
TNF-α, IL-4, IL-6, and IL-10 serum cytokines were analyzed using multiplexed Cytometric Bead Array in 161 samples from endemic areas in the Brazilian Amazon: SI [AVL] (21 cases), III (49), SRI (19), SOI (12), AI (36), and a control group [CG] (24).
The highest IL-6 serum levels were observed in the SI profile (AVL); higher IL-10 serum levels were observed in SI than in SOI or CG and in AI and III than in SOI; higher TNF-α serum levels were seen in SI than in CG.
Positive correlations were found between IL-6 and IL-10 serum levels in the SI and III profiles and between IL-6 and TNF-α and between IL-4 and TNF-α in the III profile.
These results provide strong evidence for associating IL-6 and IL-10 with the immunopathogenesis of AVL and help clarify the role of these cytokines in the infection spectrum.
American Psychological Association (APA)
Ramos, Patrícia Karla& Carvalho, Karina Inácio& Rosa, Daniela Santoro& Rodrigues, Ana Paula& Lima, Luciana Vieira& Campos, Marliane Batista…[et al.]. 2016. Serum Cytokine Responses over the Entire Clinical-Immunological Spectrum of Human Leishmania (L.) infantum chagasi Infection. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098631
Modern Language Association (MLA)
Ramos, Patrícia Karla…[et al.]. Serum Cytokine Responses over the Entire Clinical-Immunological Spectrum of Human Leishmania (L.) infantum chagasi Infection. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098631
American Medical Association (AMA)
Ramos, Patrícia Karla& Carvalho, Karina Inácio& Rosa, Daniela Santoro& Rodrigues, Ana Paula& Lima, Luciana Vieira& Campos, Marliane Batista…[et al.]. Serum Cytokine Responses over the Entire Clinical-Immunological Spectrum of Human Leishmania (L.) infantum chagasi Infection. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098631