Thermal Response of In Vivo Human Skin to Fractional Radiofrequency Microneedle Device
Joint Authors
Wanitphakdeedecha, Rungsima
Hanamornroongruang, Suchanan
Manuskiatti, Woraphong
Pattanaprichakul, Penvadee
Sitthinamsuwan, Panitta
Chu-ongsakol, Sorawuth
Inthasotti, Siriluk
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Fractional radiofrequency microneedle system (FRMS) is a novel fractional skin resurfacing system.
Data on thermal response to this fractional resurfacing technique is limited.
Objectives.
To investigate histologic response of in vivo human skin to varying energy settings and pulse stacking of a FRMS in dark-skinned subjects.
Methods.
Two female volunteers who were scheduled for abdominoplasty received treatment with a FRMS with varying energy settings at 6 time periods including 3 months, 1 month, 1 week, 3 days, 1 day, and the time immediately before abdominoplasty.
Biopsy specimens were analyzed using hematoxylin and eosin (H&E), Verhoeff-Van Gieson (VVG), colloidal iron, and Fontana-Masson stain.
Immunohistochemical study was performed by using Heat Shock Protein 70 (HSP70) antibody and collagen III monoclonal antibody.
Results.
The average depth of radiofrequency thermal zone (RFTZ) ranged from 100 to 300 μm, correlating with energy levels.
Columns of cell necrosis and collagen denaturation followed by inflammatory response were initially demonstrated, with subsequent increasing of mucin at 1 and 3 months after treatment.
Immunohistochemical study showed positive stain with HSP70.
Conclusion.
A single treatment with a FRMS using appropriate energy setting induces neocollagenesis.
This wound healing response may serve as a mean to improve the appearance of photodamaged skin and atrophic scars.
American Psychological Association (APA)
Manuskiatti, Woraphong& Pattanaprichakul, Penvadee& Inthasotti, Siriluk& Sitthinamsuwan, Panitta& Hanamornroongruang, Suchanan& Wanitphakdeedecha, Rungsima…[et al.]. 2016. Thermal Response of In Vivo Human Skin to Fractional Radiofrequency Microneedle Device. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098633
Modern Language Association (MLA)
Manuskiatti, Woraphong…[et al.]. Thermal Response of In Vivo Human Skin to Fractional Radiofrequency Microneedle Device. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098633
American Medical Association (AMA)
Manuskiatti, Woraphong& Pattanaprichakul, Penvadee& Inthasotti, Siriluk& Sitthinamsuwan, Panitta& Hanamornroongruang, Suchanan& Wanitphakdeedecha, Rungsima…[et al.]. Thermal Response of In Vivo Human Skin to Fractional Radiofrequency Microneedle Device. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098633