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A Five-Gene Expression Signature Predicts Clinical Outcome of Ovarian Serous Cystadenocarcinoma
Joint Authors
Liu, Li-Wei
Zhang, Qiuhao
Guo, Wenna
Qian, Kun
Wang, Qiang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Ovarian serous cystadenocarcinoma is a common malignant tumor of female genital organs.
Treatment is generally less effective as patients are usually diagnosed in the late stage.
Therefore, a well-designed prognostic marker provides valuable data for optimizing therapy.
In this study, we analyzed 303 samples of ovarian serous cystadenocarcinoma and the corresponding RNA-seq data.
We observed the correlation between gene expression and patients’ survival and eventually established a risk assessment model of five factors using Cox proportional hazards regression analysis.
We found that the survival time in high-risk patients was significantly shorter than in low-risk patients in both training and testing sets after Kaplan-Meier analysis.
The AUROC value was 0.67 when predicting the survival time in testing set, which indicates a relatively high specificity and sensitivity.
The results suggest diagnostic and therapeutic applications of our five-gene model for ovarian serous cystadenocarcinoma.
American Psychological Association (APA)
Liu, Li-Wei& Zhang, Qiuhao& Guo, Wenna& Qian, Kun& Wang, Qiang. 2016. A Five-Gene Expression Signature Predicts Clinical Outcome of Ovarian Serous Cystadenocarcinoma. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098634
Modern Language Association (MLA)
Liu, Li-Wei…[et al.]. A Five-Gene Expression Signature Predicts Clinical Outcome of Ovarian Serous Cystadenocarcinoma. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1098634
American Medical Association (AMA)
Liu, Li-Wei& Zhang, Qiuhao& Guo, Wenna& Qian, Kun& Wang, Qiang. A Five-Gene Expression Signature Predicts Clinical Outcome of Ovarian Serous Cystadenocarcinoma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098634