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PET Evidence of the Effect of Donepezil on Cognitive Performance in an Animal Model of Chemobrain
Joint Authors
Shim, Insop
Kim, Jin Su
Lim, Ilhan
Joung, Hye-Young
Yu, A Ram
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A considerable number of patients with breast cancer complain of cognitive impairment after chemotherapy.
In this study, we showed that donepezil enhanced memory function and increased brain glucose metabolism in a rat model of cognitive impairment after chemotherapy using behavioral analysis and positron emission tomography (PET).
We found that chemotherapy affected spatial learning ability, reference memory, and working memory and that donepezil improved these cognitive impairments.
According to PET analysis, chemotherapy reduced glucose metabolism in the medial prefrontal cortex and hippocampus, and donepezil increased glucose metabolism in the bilateral frontal lobe, parietal lobe, and hippocampus.
Reduced glucose metabolism was more prominent after treatment with doxorubicin than cyclophosphamide.
Our results demonstrated the neural mechanisms for cognitive impairment after chemotherapy and show that cognition was improved after donepezil intervention using both behavioral and imaging methods.
Our results suggested that donepezil can be employed clinically for the treatment of cognitive deficits after chemotherapy.
American Psychological Association (APA)
Lim, Ilhan& Joung, Hye-Young& Yu, A Ram& Shim, Insop& Kim, Jin Su. 2016. PET Evidence of the Effect of Donepezil on Cognitive Performance in an Animal Model of Chemobrain. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098635
Modern Language Association (MLA)
Lim, Ilhan…[et al.]. PET Evidence of the Effect of Donepezil on Cognitive Performance in an Animal Model of Chemobrain. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098635
American Medical Association (AMA)
Lim, Ilhan& Joung, Hye-Young& Yu, A Ram& Shim, Insop& Kim, Jin Su. PET Evidence of the Effect of Donepezil on Cognitive Performance in an Animal Model of Chemobrain. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098635