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Analyses of Genetic Variations of Glutathione S-Transferase Mu1 and Theta1 Genes in Bangladeshi Tannery Workers and Healthy Controls
Joint Authors
Nabi, A. H. M. Nurun
Hossain, Mahmud
Akther, Jobaida
Ebihara, Akio
Nakagawa, Tsutomu
Islam, Laila N.
Suzuki, Fumiaki
Hosen, Md. Ismail
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Glutathione S-transferases (GSTs) belong to a group of multigene detoxification enzymes, which defend cells against oxidative stress.
Tannery workers are at risk of oxidative damage that is usually detoxified by GSTs.
This study investigated the genotypic frequencies of GST Mu1 (GSTM1) and GST Theta1 (GSTT1) in Bangladeshi tannery workers and healthy controls followed by their status of oxidative stress and total GST activity.
Of the 188 individuals, 50.0% had both GSTM1 and GSTT1 (+/+), 12.2% had GSTM1 (+/−), 31.4% had GSTT1 (−/+) alleles, and 6.4% had null genotypes (−/−) with respect to both GSTM1 and GSTT1 alleles.
Among 109 healthy controls, 54.1% were double positive, 9.2% had GSTM1 allele, 32.1% had GSTT1 allele, and 4.6% had null genotypes.
Out of 79 tannery workers, 44.3% were +/+, 16.8% were +/−, 30.5% were −/+, and 8.4% were −/−.
Though the polymorphic genotypes or allelic variants of GSTM1 and GSTT1 were distributed among the study subjects with different frequencies, the differences between the study groups were not statistically significant.
GST activity did not vary significantly between the two groups and also among different genotypes while level of lipid peroxidation was significantly higher in tannery workers compared to controls irrespective of their GST genotypes.
American Psychological Association (APA)
Akther, Jobaida& Ebihara, Akio& Nakagawa, Tsutomu& Islam, Laila N.& Suzuki, Fumiaki& Hosen, Md. Ismail…[et al.]. 2016. Analyses of Genetic Variations of Glutathione S-Transferase Mu1 and Theta1 Genes in Bangladeshi Tannery Workers and Healthy Controls. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098642
Modern Language Association (MLA)
Akther, Jobaida…[et al.]. Analyses of Genetic Variations of Glutathione S-Transferase Mu1 and Theta1 Genes in Bangladeshi Tannery Workers and Healthy Controls. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098642
American Medical Association (AMA)
Akther, Jobaida& Ebihara, Akio& Nakagawa, Tsutomu& Islam, Laila N.& Suzuki, Fumiaki& Hosen, Md. Ismail…[et al.]. Analyses of Genetic Variations of Glutathione S-Transferase Mu1 and Theta1 Genes in Bangladeshi Tannery Workers and Healthy Controls. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098642