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Effect of TRPV4-p38 MAPK Pathway on Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion
Joint Authors
Yue, Shou-Wei
Qu, Yu-Juan
Zhang, Xiao
Fan, Zhen-Zhen
Huai, Juan
Teng, Yong-Bo
Zhang, Yang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of this study was to investigate the relationships among TRPV4, p38, and neuropathic pain in a rat model of chronic compression of the dorsal root ganglion.
Mechanical allodynia appeared after CCD surgery, enhanced via the intrathecal injection of 4α-phorbol 12,13-didecanoate (4α-PDD, an agonist of TRPV4) and anisomycin (an agonist of p38), but was suppressed by Ruthenium Red (RR, an inhibitor of TRPV4) and SB203580 (an inhibitor of p38).
The protein expressions of p38 and P-p38 were upregulated by 4α-PDD and anisomycin injection but reduced by RR and SB203580.
Moreover, TRPV4 was upregulated by 4α-PDD and SB203580 and downregulated by RR and anisomycin.
In DRG tissues, the numbers of TRPV4- or p38-positive small neurons were significantly changed in CCD rats, increased by the agonists, and decreased by the inhibitors.
The amplitudes of ectopic discharges were increased by 4α-PDD and anisomycin but decreased by RR and SB203580.
Collectively, these results support the link between TRPV4 and p38 and their intermediary role for neuropathic pain in rats with chronic compression of the dorsal root ganglion.
American Psychological Association (APA)
Qu, Yu-Juan& Zhang, Xiao& Fan, Zhen-Zhen& Huai, Juan& Teng, Yong-Bo& Zhang, Yang…[et al.]. 2016. Effect of TRPV4-p38 MAPK Pathway on Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098643
Modern Language Association (MLA)
Qu, Yu-Juan…[et al.]. Effect of TRPV4-p38 MAPK Pathway on Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1098643
American Medical Association (AMA)
Qu, Yu-Juan& Zhang, Xiao& Fan, Zhen-Zhen& Huai, Juan& Teng, Yong-Bo& Zhang, Yang…[et al.]. Effect of TRPV4-p38 MAPK Pathway on Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098643
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098643