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Activity of Proteolytic Enzymes and Level of Cystatin C in the Peripartum Period
Joint Authors
Pączek, Leszek
Wyczalkowska-Tomasik, Aleksandra
Cyganek, Anna
Jarmuzek, Patrycja
Grzechocinska, Barbara
Jabiry-Zieniewicz, Zoulikha
Wielgos, Miroslaw
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
The aim of the study was to evaluate the activity of cathepsin B, collagenases, trypsin, and plasmin and concentration of cystatin C in serum of healthy pregnant women in peripartum period.
Study Design.
The study group included 45 women in uncomplicated pregnancies.
Blood samples were collected in four time points.
Enzyme activity was measured by spectrofluorometric method.
The level of cystatin C was measured using immunonephelometric method.
Results.
Mean activity of cathepsin B and the level of serum cystatin C were significantly higher in the study group.
Collagenase activity was significantly lower in the study group than the control group.
No differences in collagenase, plasmin, and trypsin activity on each day of the peripartum period were found.
Conclusion.
High activity of cathepsin B and increased level of cystatin C are typical for women in late pregnancy.
Those levels significantly decrease after delivery which can be associated with potential role of those markers in placental separation.
The insignificant changes of cystatin C level in the peripartum period seem to exclude the possibility of using cystatin C as a marker for renal insufficiency in the peripartum period but additional research is necessary to investigate the matter further.
American Psychological Association (APA)
Cyganek, Anna& Wyczalkowska-Tomasik, Aleksandra& Jarmuzek, Patrycja& Grzechocinska, Barbara& Jabiry-Zieniewicz, Zoulikha& Pączek, Leszek…[et al.]. 2016. Activity of Proteolytic Enzymes and Level of Cystatin C in the Peripartum Period. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1098668
Modern Language Association (MLA)
Cyganek, Anna…[et al.]. Activity of Proteolytic Enzymes and Level of Cystatin C in the Peripartum Period. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1098668
American Medical Association (AMA)
Cyganek, Anna& Wyczalkowska-Tomasik, Aleksandra& Jarmuzek, Patrycja& Grzechocinska, Barbara& Jabiry-Zieniewicz, Zoulikha& Pączek, Leszek…[et al.]. Activity of Proteolytic Enzymes and Level of Cystatin C in the Peripartum Period. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1098668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098668